{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T17:15:51Z","timestamp":1782580551534,"version":"3.54.5"},"reference-count":26,"publisher":"SAGE Publications","issue":"6_suppl","license":[{"start":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T00:00:00Z","timestamp":1289433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Drug delivery into the posterior segment of the eye is complicated by the presence of the blood-ocular barrier. Strategies for delivering drugs to the posterior segment include systemic administration, modification of the blood-eye barrier, and local drug delivery. Recently, new topical treatments have emerged for the treatment of posterior eye disease. Iontophoretic, juxtascleral, and intravitreal routes can be used to achieve therapeutic levels in the posterior segment. Extended-release intravitreal drug delivery systems can achieve sustained therapeutic levels with the goal of providing a prolonged clinical benefit.<\/jats:p>","DOI":"10.5301\/ejo.2010.6051","type":"journal-article","created":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T15:17:33Z","timestamp":1290007053000},"page":"20-26","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Drug Delivery to the Posterior Segment of the Eye"],"prefix":"10.1177","volume":"21","author":[{"given":"Naomi","family":"Fischer","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv - Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Narayanan","sequence":"additional","affiliation":[{"name":"LV Prasad Eye Institute, Hyderabad - India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Loewenstein","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv - Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baruch D.","family":"Kuppermann","sequence":"additional","affiliation":[{"name":"Gavin Herbert Eye Institute, University of California, Irvine, California - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,11,11]]},"reference":[{"key":"bibr1-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2005.09.004"},{"key":"bibr2-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2006.07.027"},{"key":"bibr3-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(82)90017-1"},{"key":"bibr4-EJO.2010.6051","first-page":"584","volume":"26","author":"Ahmed I.","year":"1985","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr5-EJO.2010.6051","first-page":"961","volume":"41","author":"Geroski D.H.","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr6-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(02)00326-0"},{"key":"bibr7-EJO.2010.6051","first-page":"1893","volume":"36","author":"Olsen T.W.","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr8-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1159\/000228926"},{"key":"bibr9-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-07-0193"},{"key":"bibr10-EJO.2010.6051","first-page":"543","volume":"46","author":"Wirtz R.","year":"1908","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"bibr11-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200012000-00007"},{"key":"bibr12-EJO.2010.6051","first-page":"391","volume":"26","author":"Halhal M.","year":"2003","journal-title":"J Fr Ophtalmol"},{"key":"bibr13-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.09.038"},{"key":"bibr14-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0378-3"},{"key":"bibr15-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2008.0087"},{"key":"bibr16-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2006.11.005"},{"key":"bibr17-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054481"},{"key":"bibr18-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062655"},{"key":"bibr19-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.304"},{"key":"bibr20-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.6.1506"},{"key":"bibr21-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090240037023"},{"key":"bibr22-EJO.2010.6051","volume":"47","author":"Pearson P.","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr23-EJO.2010.6051","unstructured":"Form 8-K filed to the United States Securities and Exchange Commission by PsiVida Corporation on December 23, 2009, which reported the 24-month results of the two phase 3 pivotal clinical trials (FAME\u2122 Study) for Iluvien\u00ae in the treatment of diabetic macular edema."},{"key":"bibr24-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.3.309"},{"key":"bibr25-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.03.032"},{"key":"bibr26-EJO.2010.6051","doi-asserted-by":"publisher","DOI":"10.1159\/000318021"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/EJO.2010.6051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/EJO.2010.6051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:36:11Z","timestamp":1777404971000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/EJO.2010.6051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,11]]},"references-count":26,"journal-issue":{"issue":"6_suppl","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.5301\/EJO.2010.6051"],"URL":"https:\/\/doi.org\/10.5301\/ejo.2010.6051","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,11]]}}}