{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:36:07Z","timestamp":1791916567805,"version":"4.3.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>TO report on intravitreal bevacizumab treatment for external beam radiation therapy (EBRT)-related radiation maculopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three patients (4 eyes) with EBRT-related maculopathy were treated with periodic (4- to 8-week) intravitreal injections of bevacizumab (1.25 mg in 0.05 cc). Outcome measures included best-corrected Early Treatment Diabetic Retinopathy Study visual acuity, retinal examination, fundus photography, fluorescein angiography, and optical coherence tomography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients were diagnosed with Stage 3 radiation maculopathy occurring 12, 19, and 48 months after irradiation. One received 50 Gy of 6-MV photon EBRT for a maxillary carcinoma, the second 30.6 Gy of 6-MV photon EBRT for intraocular lymphoma, and the third 72 Gy proton beam irradiation for adenoid cystic carcinoma of the lacrimal gland. With up to 33 months follow-up, visual acuities improved (8 and 11 letters) in 2 eyes, gained 5 letters in 1 eye and 1 decreased 5 letters from 20\/16 to 20\/20. All cases demonstrated clinical findings of decreased intraretinal hemorrhages, cotton-wool spots, and retinal edema. There were no significant ocular or systemic side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intravitreal anti-VEGF therapy was associated with reductions of EBRT-related retinopathy. No ocular or systemic side effects were noted. Anti-VEGF therapy may be considered radiation maculopathy secondary to EBRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.2011.6213","type":"journal-article","created":{"date-parts":[[2011,1,3]],"date-time":"2011-01-03T07:03:59Z","timestamp":1294038239000},"page":"446-451","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Intravitreal Anti-VEGF Bevacizumab (Avastin) for External Beam-Related Radiation Retinopathy"],"prefix":"10.1177","volume":"21","author":[{"given":"Paul T.","family":"Finger","sequence":"first","affiliation":[{"name":"The New York Eye Cancer Center, New York, New York - USA"},{"name":"The New York Eye and Ear Infirmary, New York, New York - USA"},{"name":"New York University School of Medicine, New York, New York - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Krishna","family":"Mukkamala","sequence":"additional","affiliation":[{"name":"The New York Eye and Ear Infirmary, New York, New York - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,3,1]]},"reference":[{"key":"bibr1-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-7-6"},{"key":"bibr2-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.11.006"},{"key":"bibr3-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.12.027"},{"key":"bibr4-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2009.06.004"},{"key":"bibr5-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)90347-6"},{"key":"bibr6-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00057-7"},{"key":"bibr7-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.3109\/02713689309029227"},{"key":"bibr8-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)00088-X"},{"key":"bibr9-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702820"},{"key":"bibr10-EJO.2011.6213","first-page":"98","volume":"13","author":"Borruat F.X.","year":"1993","journal-title":"J Clin Neuroophthalmol"},{"key":"bibr11-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.052159"},{"key":"bibr12-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.65.9.623"},{"key":"bibr13-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1007\/s12009-006-0013-2"},{"key":"bibr14-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.6.751"},{"key":"bibr15-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.11.045"},{"key":"bibr16-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.376"},{"key":"bibr17-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.00977.x"},{"key":"bibr18-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S7051"},{"key":"bibr19-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)90346-8"},{"key":"bibr20-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31806e6042"},{"key":"bibr21-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181706302"},{"key":"bibr22-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2009.7"},{"key":"bibr23-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181633fee"},{"key":"bibr24-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6703018"},{"key":"bibr25-EJO.2011.6213","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.09.014"},{"key":"bibr26-EJO.2011.6213","author":"Finger P.T.","year":"2011","journal-title":"J Radiat Oncol Biol Phys"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/EJO.2011.6213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/EJO.2011.6213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:35:56Z","timestamp":1777404956000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/EJO.2011.6213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,1]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.5301\/EJO.2011.6213"],"URL":"https:\/\/doi.org\/10.5301\/ejo.2011.6213","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,1]]}}}