{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:54:56Z","timestamp":1777578896227,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T00:00:00Z","timestamp":1296172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the usefulness of magnetic resonance imaging (MRI) in assessing fibrovascularization progression into synthetic hydroxyapatite (HA) implants inserted in anophthalmic sockets of children submitted to enucleation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 23 HA orbital implants in 23 children who underwent enucleation for retinoblastoma. Each patient was examined by MRI within to 9 to 69 weeks after implant insertion (mean 34 weeks, median 30 weeks). No patient had received chemotherapy or radiotherapy at MRI examination. From each T1-weighted, fat-suppressed enhanced axial examination, the image depicting the center of the implant was identified. Enhancement was evaluated using a 5-point scale. Additionally, possible associated orbital and intracranial pathologies and implant migration or extrusion were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All patients showed areas of enhancement of the implant consistent with the presence of fibrovascular ingrowth. There was no grade 1 enhancement in our series. Grade 2 was observed in 1 patient (4.34%), grade 3 in 7 patients (30.43%), grade 4 in 11 patients (47.82%), and grade 5 in 4 patients (17.39%). During follow-up there were no cases of clinically evident orbital infection, implant migration, or implant extrusion. No second tumor, optic nerve invasion, orbital extension, tumor relapse, or leptomeningeal brain seeding were noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this series, enhanced MRI showed satisfactory fibrovascular ingrowth of orbital implants since the 13th week after HA spheres insertion, with a trend towards progressive enhancement during the following weeks. The data also confirm the advice to wait at least 5\u20136 months after enucleation to perform drilling and peg placement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.2011.6298","type":"journal-article","created":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T11:57:00Z","timestamp":1296215820000},"page":"521-528","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Contrast-Enhanced Magnetic Resonance Imaging of Fibrovascular Tissue Ingrowth within Synthetic Hydroxyapatite Orbital Implants in Children"],"prefix":"10.1177","volume":"21","author":[{"given":"Paolo","family":"Galluzzi","sequence":"first","affiliation":[{"name":"Neuro-Imaging and Neuro-Interventional (NINT) Unit, Azienda Ospedaliera e Universitaria Senese, Policlinico Santa Maria alle Scotte, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"De Francesco","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Referral Center for Retinoblastoma, University of Siena, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Giacalone","sequence":"additional","affiliation":[{"name":"Radiology Unit, University of Siena, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Cerase","sequence":"additional","affiliation":[{"name":"Neuro-Imaging and Neuro-Interventional (NINT) Unit, Azienda Ospedaliera e Universitaria Senese, Policlinico Santa Maria alle Scotte, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Monti","sequence":"additional","affiliation":[{"name":"Neuro-Imaging and Neuro-Interventional (NINT) Unit, Azienda Ospedaliera e Universitaria Senese, Policlinico Santa Maria alle Scotte, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignazio Maria","family":"Vallone","sequence":"additional","affiliation":[{"name":"Neuro-Imaging and Neuro-Interventional (NINT) Unit, Azienda Ospedaliera e Universitaria Senese, Policlinico Santa Maria alle Scotte, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Lazzeretti","sequence":"additional","affiliation":[{"name":"Radiology Unit, University of Siena, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Venturi","sequence":"additional","affiliation":[{"name":"Neuro-Imaging and Neuro-Interventional (NINT) Unit, Azienda Ospedaliera e Universitaria Senese, Policlinico Santa Maria alle Scotte, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodora","family":"Hadjistilianou","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Referral Center for Retinoblastoma, University of Siena, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,1,28]]},"reference":[{"key":"bibr1-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)31918-9"},{"key":"bibr2-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71228-0"},{"key":"bibr3-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1007\/BF00596547"},{"key":"bibr4-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-199606000-00007"},{"key":"bibr5-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-8389(05)70236-0"},{"key":"bibr6-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1999.51"},{"key":"bibr7-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2006.01222.x"},{"key":"bibr8-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-200301000-00006"},{"key":"bibr9-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2009.06.003"},{"key":"bibr10-EJO.2011.6298","first-page":"75","volume":"8","author":"Perry A.C.","year":"1990","journal-title":"Adv Ophthalmic Plast Reconstr Surg"},{"key":"bibr11-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2006.12.007"},{"key":"bibr12-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.9.702"},{"key":"bibr13-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.6.826"},{"key":"bibr14-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72323-2"},{"key":"bibr15-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1606.1999.00160.x"},{"key":"bibr16-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-199412000-00009"},{"key":"bibr17-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-199506000-00001"},{"key":"bibr18-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1998.6"},{"key":"bibr19-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-199606000-00008"},{"key":"bibr20-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30427-2"},{"key":"bibr21-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30991-8"},{"key":"bibr22-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5155(03)00137-0"},{"key":"bibr23-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)97040-3"},{"key":"bibr24-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00016-6"},{"key":"bibr25-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.04.062"},{"key":"bibr26-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.18904"},{"key":"bibr27-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00249-9"},{"key":"bibr28-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1076\/orbi.22.3.183.15615"},{"key":"bibr29-EJO.2011.6298","doi-asserted-by":"publisher","DOI":"10.1177\/112067219900900408"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/EJO.2011.6298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/EJO.2011.6298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:36:01Z","timestamp":1777404961000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/EJO.2011.6298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,28]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.5301\/EJO.2011.6298"],"URL":"https:\/\/doi.org\/10.5301\/ejo.2011.6298","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,28]]}}}