{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T18:52:56Z","timestamp":1778007176017,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T00:00:00Z","timestamp":1315180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>Neurofibromatosis type 1 (NF-1) complicates various tumors originating from the neural crest. The authors report a case of NF-1 presenting with globe enlargement and subretinal and choroidal neovascularization associated with choroidal ganglioneuroma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>A 7-year-old boy with NF-1 had severe ocular pain OS. He has a medical history of congenital glaucoma OS. Left eye showed increased intraocular pressure, buphthalmos, corneal opacity, hyphema, and vitreous hemorrhage. Magnetic resonance imaging indicated prominent vitreous hemorrhage and a choroidal tumor. Enucleation was consequently performed OS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Histopathologic diagnosis of the choroidal tumor was ganglioneuroma admixed with micro-vessels and melanocytes. There was a huge subretinal and choroidal fibrovascular membrane formation originating from the choroidal ganglioneuroma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Severe ocular pain in this patient was caused by intraocular neovascularization and subsequent increased eyeball content by vitreous hemorrhage associated with the choroidal tumor. In NF-1 with orbitofacial involvement, detection of intraocular tumor by imaging tests may predict tumor-associated severe ophthalmic complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.2011.8317","type":"journal-article","created":{"date-parts":[[2011,5,9]],"date-time":"2011-05-09T10:21:35Z","timestamp":1304936495000},"page":"837-840","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Intraocular Neovascularization Associated with Choroidal Ganglioneuroma in Neurofibromatosis Type 1"],"prefix":"10.1177","volume":"21","author":[{"given":"Kan","family":"Ishijima","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Hokkaido - Japan"},{"name":"Department of Ophthalmology, Hokkaido Tokeidaikinen Hospital, Hokkaido - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Kase","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Hokkaido - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Hokkaido - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Hokkaido - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,9,5]]},"reference":[{"key":"bibr1-EJO.2011.8317","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702320"},{"key":"bibr2-EJO.2011.8317","doi-asserted-by":"publisher","DOI":"10.1007\/BF02307012"},{"key":"bibr3-EJO.2011.8317","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00630.x"},{"key":"bibr4-EJO.2011.8317","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-197095"},{"key":"bibr5-EJO.2011.8317","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.06.019"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/EJO.2011.8317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/EJO.2011.8317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:36:10Z","timestamp":1777404970000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/EJO.2011.8317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,5]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.5301\/EJO.2011.8317"],"URL":"https:\/\/doi.org\/10.5301\/ejo.2011.8317","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,5]]}}}