{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:55:50Z","timestamp":1777578950006,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T00:00:00Z","timestamp":1315180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the following in patients with aniridia: age at first examination at the University Eye Hospital and age at diagnosis of glaucoma; visual acuity; frequency of family history of aniridia; and frequency of ocular and general diseases associated with aniridia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a consecutive examination of 30 unrelated patients with aniridia and retrospective evaluation of ophthalmologic, pediatric, and internal findings. The relative frequency of age at glaucoma diagnosis within decades was evaluated for the 20 patients with aniridia and glaucoma. Statistical analysis was performed using the Mann-Whitney test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Relative frequency of the age of patients with aniridia at time of glaucoma diagnosis within the following decades was as follows: from birth to 9 years: 15%, 10-19: 15%, 20-29: 15%, 30-39: 15%, 40-49: 35%, and 50-59: 5%. Visual acuity in the better eye of 20\/100 or less was found in 60%. Family history of aniridia was found in 33.3% of patients, with 1-4 relatives with aniridia. A total of 76.7% of patients had congenital cataract, and 66.7% had glaucoma. Mean maximum intraocular pressure of the 20 patients with glaucoma was 35.9 mmHg in the right and 32.6 mmHg in the left eye. A total of 53.3% had nystagmus, 26.6% corneal opacifications, 16.7% bilateral lens dislocation upwards, 6.7% optic nerve hypoplasia, 3.3% poor foveal development, and 3.3% Wilms tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Up to the age of 40 years, 15% of patients were diagnosed with glaucoma per age decade. Frequent bilateral glaucoma and similar bilateral height of intraocular pressure suggest a genetic glaucoma disposition with malformation at Schlemm canal, besides possible sequential anatomic changes in the chamber angle. Associated ocular abnormalities limit visual prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.2011.8318","type":"journal-article","created":{"date-parts":[[2011,5,9]],"date-time":"2011-05-09T12:13:44Z","timestamp":1304943224000},"page":"104-110","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Glaucoma and Frequency of Ocular and General Diseases in 30 Patients with Aniridia: A Clinical Study"],"prefix":"10.1177","volume":"22","author":[{"given":"Eugen","family":"Gramer","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University W\u00fcrzburg, W\u00fcrzburg - Germany"},{"name":"University Hospital for Pediatric and Adolescent Medicine, University Heidelberg, Heidelberg - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"Reiter","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University W\u00fcrzburg, W\u00fcrzburg - Germany"},{"name":"University Hospital for Pediatric and Adolescent Medicine, University Heidelberg, Heidelberg - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwendolyn","family":"Gramer","sequence":"additional","affiliation":[{"name":"University Hospital for Pediatric and Adolescent Medicine, University Heidelberg, Heidelberg - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,9,5]]},"reference":[{"key":"bibr1-EJO.2011.8318","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.12.012"},{"key":"bibr2-EJO.2011.8318","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(84)90184-X"},{"key":"bibr3-EJO.2011.8318","first-page":"1286","volume":"51","author":"Fantes J.A.","year":"1992","journal-title":"Am J Hum Genet"},{"key":"bibr4-EJO.2011.8318","unstructured":"GramerG. Familienanamnese, genetisches Risikoprofil und Risikofaktoren der Glaukome. Eine Untersuchung von 2170 Patienten mit Glaukom oder okul\u00e4rer Hypertension. Inauguraldissertation Med Fakult\u00e4t, Universit\u00e4t W\u00fcrzburg 2006. Available at: http:\/\/www.opus-bayern.de\/uni-wuerzburg\/volltexte\/2006\/1997"},{"key":"bibr5-EJO.2011.8318","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31819f9330"},{"key":"bibr6-EJO.2011.8318","first-page":"859","volume-title":"The Glaucomas (ch 40).","author":"Mintz-Hittner H.A.","year":"1996"},{"key":"bibr7-EJO.2011.8318","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-200404410-00008"},{"key":"bibr8-EJO.2011.8318","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(74)90308-0"},{"key":"bibr9-EJO.2011.8318","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0b013e318169314b"},{"key":"bibr10-EJO.2011.8318","first-page":"528","volume":"163","author":"Delleman J.W.","year":"1973","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"bibr11-EJO.2011.8318","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32209"},{"key":"bibr12-EJO.2011.8318","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.089698"},{"key":"bibr13-EJO.2011.8318","doi-asserted-by":"publisher","DOI":"10.1038\/354522a0"},{"key":"bibr14-EJO.2011.8318","doi-asserted-by":"publisher","DOI":"10.1126\/science.7914031"},{"key":"bibr15-EJO.2011.8318","volume":"50","author":"Reiter C.","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr16-EJO.2011.8318","unstructured":"HammersteinW. Genetische Beratung in der Augenheilkunde. B\u00fccherei des Augenarztes, Herausgeber G.O.H. 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