{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:55:56Z","timestamp":1777578956153,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,6,13]],"date-time":"2011-06-13T00:00:00Z","timestamp":1307923200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the efficacy, safety, and tolerability of Timogel\u00ae preservative-free once daily compared to timolol 0.5% ophthalmic solution bid in patients with ocular hypertension (OHT) and patients with primary open-angle glaucoma (POAG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 75 patients with OHT and patients with POAG treated with timolol 0.5% bid with intraocular pressure (IOP) \u226421 mmHg were enrolled. They underwent complete ophthalmologic examination, IOP measurements (at trough and daytime curve), evaluation of side effects, Schirmer test, break-up time [BUT], blood pressure, heart rate, ocular diastolic perfusion pressure measurements, and acceptance (Comparison of Ophthalmic Medications for Tolerability). Patients switched to Timogel\u00ae and were re-evaluated 3 months later. The analysis of variance and the Pearson \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests were used to test differences between the treatments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intraocular pressure reduction at trough was 23.6% with timolol 0.5% and 22.3% with Timogel\u00ae. No statistical differences were observed in IOP values at trough and in the daytime curve between the 2 treatments. Local and systemic side effects were less frequent with Timogel\u00ae (hazard ratio: p&lt;0.05). Patients demonstrated a significant improvement of Schirmer test and BUT (p&lt;0.05) and a reduction of dryness and foreign body sensation (42.6% vs 15.4%; p&lt;0.01) after switching to Timogel\u00ae. Mild and short-lasting blurred vision after Timogel\u00ae instillation occurred in about 18.5% of patients. A total of 82% of patients were satisfied or very satisfied with Timogel\u00ae vs 61% with previous treatment (p&lt;0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Timogel\u00ae preservative-free dosed once every morning has a 24-hour hypotensive effect with a better safety profile than timolol 0.5% bid and it is well-accepted by patients. The once-daily dosing improved acceptance and compliance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000006","type":"journal-article","created":{"date-parts":[[2011,6,13]],"date-time":"2011-06-13T08:08:06Z","timestamp":1307952486000},"page":"28-33","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Timogel\u00ae vs Timolol 0.5% Ophthalmic Solution: Efficacy, Safety, and Acceptance"],"prefix":"10.1177","volume":"22","author":[{"given":"Teresa","family":"Rolle","sequence":"first","affiliation":[{"name":"Department of Clinical Physiopathology, Section of Ophthalmology, Eye Clinic, University of Torino, Torino - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Curto","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiopathology, Section of Ophthalmology, Eye Clinic, University of Torino, Torino - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Alovisi","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiopathology, Section of Ophthalmology, Eye Clinic, University of Torino, Torino - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Franzone","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiopathology, Section of Ophthalmology, Eye Clinic, University of Torino, Torino - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Brogliatti","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiopathology, Section of Ophthalmology, Eye Clinic, University of Torino, Torino - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico M.","family":"Grignolo","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiopathology, Section of Ophthalmology, Eye Clinic, University of Torino, Torino - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,6,13]]},"reference":[{"key":"bibr1-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.5.389"},{"key":"bibr2-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)92665-3"},{"key":"bibr3-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"bibr4-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.6.701"},{"key":"bibr5-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00873-9"},{"key":"bibr6-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00538-9"},{"key":"bibr7-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00272-4"},{"key":"bibr8-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.35.020184.001211"},{"key":"bibr9-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(01)80048-5"},{"key":"bibr10-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.4.418"},{"key":"bibr11-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1177\/112067210701700311"},{"key":"bibr12-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.10.019"},{"key":"bibr13-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00562.x"},{"key":"bibr14-ejo.5000006","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-002-0462-2"},{"key":"bibr15-ejo.5000006","unstructured":"European Glaucoma Society. 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