{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:55:58Z","timestamp":1777578958891,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T00:00:00Z","timestamp":1315526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine if a test formulation of latanoprost 0.005% (Bausch &amp; Lomb) eyedrops reduced intraocular pressure (IOP) as well as Xalatan\u00ae (latanoprost 0.005%) in patients with ocular hypertension (OH) or primary open-angle glaucoma (POAG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, randomized, investigator-masked, parallel-group study allocated 266 patients with OH or POAG in a 1:1 ratio to latanoprost or Xalatan administered once daily for 6 weeks. The primary endpoint was the mean change in 8:00 AM IOP of the study eye from baseline to week 6. Secondary endpoints included mean change in 8:00 AM IOP from baseline to week 2, and in 12:00 noon and 4:00 PM IOP from baseline to week 2 and week 6. The safety and tolerability of both drugs were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both study groups had comparable demographics and baseline characteristics. The mean (SD) change in 8:00 AM IOP from baseline to week 6 was \u22127.29 (2.61) and \u22127.54 (2.80) mmHg with latanoprost and Xalatan, respectively. Latanoprost was found noninferior to Xalatan in the primary analysis (mean [SEM] treatment difference, 0.252 [0.504] mmHg; 95% confidence interval [CI] \u22120.408, 0.913; p = 0.0001; noninferiority margin, 1.5 mmHg) and met the predefined definition of equivalence to Xalatan (95% CI within [\u20131.5, 1.5 mmHg] margin). The IOP-lowering effects of latanoprost and Xalatan were comparable at all assessed time points. Both study treatments demonstrated a comparable safety and tolerability profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bausch &amp; Lomb latanoprost 0.005% is clinically equivalent to Xalatan for treating OH and POAG as demonstrated through this unique comparative trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000041","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T17:23:27Z","timestamp":1315589007000},"page":"19-27","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Latanoprost 0.005% Test Formulation is as Effective as Xalatan\u00ae in Patients with Ocular Hypertension and Primary Open-Angle Glaucoma"],"prefix":"10.1177","volume":"22","author":[{"given":"Catherine","family":"Allaire","sequence":"first","affiliation":[{"name":"European Pharmaceutical Clinical Sciences, Bausch & Lomb, Evry - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Medical Affairs, Pharmaceuticals, Bausch & Lomb Swiss AG, Zug - Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Allmeier","sequence":"additional","affiliation":[{"name":"Clinical Affairs, Pharmaceuticals, Bausch & Lomb, Berlin - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iveta","family":"Grundmane","sequence":"additional","affiliation":[{"name":"I. Grundmane Private Practice in Ophthalmology, Valmiera - Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazyna","family":"Mazur-Piotrowska","sequence":"additional","affiliation":[{"name":"Prywatny Gabinet Okulistyczny, Katowice - Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pepo","family":"Neshev","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, MHAT Lovech, Lovech - Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunther","family":"Kahle","sequence":"additional","affiliation":[{"name":"Private Practice in Ophthalmology, Berlin - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,9,9]]},"reference":[{"key":"bibr1-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01452.x"},{"key":"bibr2-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1016\/S0181-5512(06)73821-9"},{"key":"bibr3-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A178"},{"key":"bibr4-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-10-10"},{"key":"bibr5-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199609050-00007"},{"key":"bibr6-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-10-4"},{"key":"bibr7-ejo.5000041","first-page":"741","volume":"4","author":"Lee A.J.","year":"2010","journal-title":"Clin Ophthalmol"},{"key":"bibr8-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.07.002"},{"key":"bibr9-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2008.08.010"},{"key":"bibr10-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.6.701"},{"key":"bibr11-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00538-9"},{"key":"bibr12-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1177\/112067210001000201"},{"key":"bibr13-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.6.579"},{"key":"bibr14-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.01.042"},{"key":"bibr15-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.1997.tb00401.x"},{"key":"bibr16-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.79.1.12"},{"key":"bibr17-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(13)31817-X"},{"key":"bibr18-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1080\/02713689808951229"},{"key":"bibr19-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1253"},{"key":"bibr20-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00605-4"},{"key":"bibr21-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1177\/112067210301304S05"},{"key":"bibr22-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.04.051"},{"key":"bibr23-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01980-3"},{"key":"bibr24-ejo.5000041","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2003.10.035"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5000041","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:36:16Z","timestamp":1777404976000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5000041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,9]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.5301\/ejo.5000041"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5000041","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,9]]}}}