{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:40:28Z","timestamp":1790484028042,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"7_suppl","license":[{"start":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T00:00:00Z","timestamp":1332115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the efficacy of pregabalin and gabapentin for reducing post\u2013photorefractive keratectomy (PRK) pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomized clinical trial, 150 subjects undergoing PRK were allocated into 3 groups. In addition to the routine regimen, pregabalin 75 mg, gabapentin 300 mg, and placebo were administered 3 times daily for 3 days, in groups 1, 2, and 3, respectively. Subjects could take acetaminophen-codeine 300\/10 mg tablets every 4 hours as needed. Patients completed a pain assessment survey (visual analogue scale ranging from 0 = no pain to 10 = most severe pain) 7 times in the first 3 days following PRK and also recorded the number of consumed acetaminophen-codeine tablets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Age, sex, refractive error, ablation depth, and mitomycin-C (MMC) application were similar in the 3 study groups (all p values&gt;0.05). Overall pain scores in the placebo group were 0.9 and 1 unit higher than the pregabalin (p=0.029) and gabapentin (p=0.023) groups, respectively. Severe pain (score &gt;7) was more frequent in the placebo group on the morning of the first postoperative day (p=0.043). The difference in the number of consumed acetaminophen-codeine tablets was statistically borderline (p=0.061) and less in the pregabalin (7.9\u00b15.2) and gabapentin (9.0\u00b14.1) groups in comparison to the placebo group (10.3\u00b15.6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pregabalin and gabapentin seem to be helpful in alleviating post-PRK pain when combined with other measures. Depending on availability, either compound can be used as an adjuvant for pain control in this setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000143","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T12:53:37Z","timestamp":1332161617000},"page":"106-113","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["Pregabalin and Gabapentin for Post-Photorefractive Keratectomy Pain: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"22","author":[{"given":"Mohammad","family":"Pakravan","sequence":"first","affiliation":[{"name":"Ophthalmic Research Center and Department of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Roshani","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Center and Department of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahin","family":"Yazdani","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Center and Department of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Faramazi","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Center and Department of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Yaseri","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran - Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,3,19]]},"reference":[{"key":"bibr1-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp033210"},{"key":"bibr2-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1076\/soph.18.1.2.14074"},{"key":"bibr3-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(98)00027-7"},{"key":"bibr4-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1007\/BF02849978"},{"key":"bibr5-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-20070201-04"},{"key":"bibr6-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2004.05.019"},{"key":"bibr7-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1007\/BF02877774"},{"key":"bibr8-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-19961101-11"},{"key":"bibr9-ejo.5000143","first-page":"CD005452","volume":"20","author":"Wiffen P.J.","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr10-ejo.5000143","first-page":"237","volume":"31","author":"Hurley R.W.","year":"2006","journal-title":"Reg Anesth Pain Med"},{"key":"bibr11-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200112000-00002"},{"key":"bibr12-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.455003.x"},{"key":"bibr13-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G078"},{"key":"bibr14-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael344"},{"key":"bibr15-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2005.12.008"},{"key":"bibr16-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565010-00011"},{"key":"bibr17-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00890-7"},{"key":"bibr18-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.11.012"},{"key":"bibr19-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.08.041"},{"key":"bibr20-ejo.5000143","first-page":"33","volume":"7","author":"Baillie J.K.","year":"2006","journal-title":"Curr Opin Investig Drugs"},{"key":"bibr21-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.025"},{"key":"bibr22-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.4161\/chan.2.1.6045"},{"key":"bibr23-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.03.005"},{"key":"bibr24-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.2165\/11536200-000000000-00000"},{"key":"bibr25-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000287643.13410.5e"},{"key":"bibr26-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1053\/eujp.2001.0235"},{"key":"bibr27-ejo.5000143","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2007.12.010"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5000143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:36:55Z","timestamp":1777405015000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5000143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,19]]},"references-count":27,"journal-issue":{"issue":"7_suppl","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.5301\/ejo.5000143"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5000143","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,19]]}}}