{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:37:04Z","timestamp":1790627824535,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To determine ocular pain duration after routine in-office intravitreal injection and to determine whether topical eyedrops are beneficial in increasing patient comfort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Forty injection-na\u00efve patients receiving routine intravitreal injections of bevacizumab for age-related macular degeneration were randomized into 3 groups: group 1 (control, no drops), group 2 (generic artificial tears), and group 3 (ketorolac tromethamine 0.4% eyedrops). Those who received topical medications were given a Visual Analog Pain score survey and asked to record their pain on a scale from 0 (no distress) to 10 (unbearable distress) daily until a score of 0 was achieved, at which point they were instructed to discontinue use of their given drops. Self-reported pain scores were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Pain after routine intravitreal injection lasts on average between 3 and 7 days. Patients receiving topical ketorolac eyedrops reported the fewest average number of pain days (2.25\u00b11.22) vs patients receiving artificial tears (3.54\u00b11.13) or those who received no postprocedure eyedrops (5.13\u00b11.25); p&lt;0.05. At most, patients receiving ketorolac eyedrops reported 3 days of recordable pain. Those who received artificial tears reported at most 5 days of recordable pain, and patients who did not receive any postprocedure eyedrops reported at most 7 days of recordable pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Pain after intravitreal injection is generally mild, may be reduced by postinjection topical ketorolac eyedrops, and lasts less than 1 week.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000147","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T14:37:44Z","timestamp":1335278264000},"page":"1008-1012","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Shortening Ocular Pain Duration following Intravitreal Injections"],"prefix":"10.1177","volume":"22","author":[{"given":"Lana","family":"Rifkin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Schaal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,4,24]]},"reference":[{"key":"bibr1-ejo.5000147","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181a94f01"},{"key":"bibr2-ejo.5000147","first-page":"CD005276","volume":"3","author":"Ezra D.G.","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr3-ejo.5000147","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.198374"},{"key":"bibr4-ejo.5000147","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181eac724"},{"key":"bibr5-ejo.5000147","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.08.031"},{"key":"bibr6-ejo.5000147","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182252ad3"},{"key":"bibr7-ejo.5000147","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200009000-00009"},{"key":"bibr8-ejo.5000147","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(92)90095-B"},{"key":"bibr9-ejo.5000147","unstructured":"Ketorolac. 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