{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:58:36Z","timestamp":1777579116091,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T00:00:00Z","timestamp":1335139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"\n Purpose<\/jats:title>\n Nephrotic syndrome is a kidney disorder characterized by loss of different plasmatic proteins resulting in different peripheral tissue edemas. No ocular complications have been reported in nephrotic syndrome secondary to primary glomerular disease.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A 24-year-old woman was referred to emergency service for acute generalized edema, associated with bilateral visual impairment and metamorphopsia. A diagnosis of nephrotic syndrome was made. The patient was treated with diuretic therapy.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n At first ophthalmologic evaluation, the woman presented best-corrected visual acuity of 20\/32 in the right eye and 20\/40 in the left eye and a dome-shaped bilateral neurosensorial retinal detachment and macular edema studied with spectral-domain optical coherence tomography. The patient underwent furosemide treatment. At follow-up evaluation 6 days later, best-corrected visual acuity improved to 20\/20 in both eyes and restoration of normal retinal anatomy was demonstrated.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Sequestration of interstitial fluids, which leads to classic generalized edema in nephrotic syndrome, could be the origin of interstitial accumulation of fluids in the retinal layers.<\/jats:p>\n <\/jats:sec>","DOI":"10.5301\/ejo.5000153","type":"journal-article","created":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T16:20:58Z","timestamp":1335198058000},"page":"843-845","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Retinal involvement in nephrotic syndrome secondary to minimal change disease"],"prefix":"10.1177","volume":"22","author":[{"given":"Umberto","family":"De Benedetto","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Vita-Salute, San Raffaele Scientific Institute, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco R.","family":"Pastore","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Vita-Salute, San Raffaele Scientific Institute, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio Battaglia","family":"Parodi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Vita-Salute, San Raffaele Scientific Institute, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bandello","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Vita-Salute, San Raffaele Scientific Institute, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Pierro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Vita-Salute, San Raffaele Scientific Institute, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,4,23]]},"reference":[{"key":"bibr1-ejo.5000153","volume-title":"Textbook of Nephrology.","author":"Massry S.G.","year":"2001"},{"key":"bibr2-ejo.5000153","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-006-1437-1"},{"key":"bibr3-ejo.5000153","doi-asserted-by":"publisher","DOI":"10.3928\/1542-8877-20010101-13"},{"key":"bibr4-ejo.5000153","unstructured":"LongoD.L., FauciA.S., KasperD.L., HauserS.L., JamesonJ.L., LoscalzoJ. Harrison's Principles of Internal Medicine, 18th ed. New York: McGraw-Hill, 2011; 2345\u20139."},{"key":"bibr5-ejo.5000153","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.00889.x"},{"key":"bibr6-ejo.5000153","doi-asserted-by":"publisher","DOI":"10.1007\/s004670000512"},{"key":"bibr7-ejo.5000153","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4537"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5000153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:36:44Z","timestamp":1777405004000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5000153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,23]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.5301\/ejo.5000153"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5000153","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,23]]}}}