{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T04:37:41Z","timestamp":1783312661995,"version":"3.54.6"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,5,6]],"date-time":"2012-05-06T00:00:00Z","timestamp":1336262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate efficacy of intravitreal injection of pegaptanib and laser photocoagulation for treatment of stage 3+ retinopathy of prematurity (ROP) affecting zone I and posterior zone II, and to compare the results in terms of regression, development of peripheral retinal vessels, and final structural outcome with conventional laser photocoagulation or combined with cryotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a prospective comparative study, 152 eyes with zone I, II posterior ROP 3+ (76 premature rabies), from 2009 to 2011, were included. Patients were randomly assigned to receive intravitreal pegaptanib (Macugen\u00ae 0.3 mg = 0.02 mL, Pfizer) with conventional diode laser photocoagulation in group 1 (68 eyes of 34 infants) or only laser therapy combined with cryotherapy in group 2 (84 eyes of 42 infants), bilaterally. The primary outcome of treatment success was defined as absence of recurrence of stage 3+ ROP. The mean follow-up after treatment was 19.3 months in group 1 and 21.5 months in group 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Final favorable anatomic outcome and stable regression of ROP at last control examination was noted in 89.7% of eyes in group 1 and 60.8 % of eyes in group 2. Regression of plus disease and peripheral retinal vessels development appeared significantly more rapidly in group 1. No recurrence of neovascularization (stage 3+ ROP) was identified in 85.4% of patients in group 1 and 50% of patients in group 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results of this study support the administration of intravitreal pegaptanib as useful therapy in the management of stage 3+ ROP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000166","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T12:32:30Z","timestamp":1338899550000},"page":"687-694","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":86,"title":["Intravitreal pegaptanib combined with diode laser therapy for stage 3+ retinopathy of prematurity in zone I and posterior zone II"],"prefix":"10.1177","volume":"22","author":[{"given":"Rudolf","family":"Autrata","sequence":"first","affiliation":[{"name":"Department of Pediatric Ophthalmology, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Brno - Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inka","family":"Krej\u010d\u00ed\u0159ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatric Ophthalmology, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Brno - Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate\u0159ina","family":"\u0160enkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatric Ophthalmology, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Brno - Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Holou\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatric Ophthalmology, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Brno - Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zden\u011bk","family":"Dole\u017eel","sequence":"additional","affiliation":[{"name":"Pediatric Clinic, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Brno - Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Borek","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Brno - Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,5,6]]},"reference":[{"key":"bibr1-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39555.670718.BE"},{"key":"bibr2-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20080501-12"},{"key":"bibr3-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2007.11.009"},{"key":"bibr4-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1067\/mpa.2000.107904"},{"key":"bibr5-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1111\/j.1395-3907.2003.00171.x"},{"key":"bibr6-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.3928\/0191-3913-20030701-06"},{"key":"bibr7-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1097\/01.iae.0000244285.79004.e6"},{"key":"bibr8-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1988.01060130517027"},{"key":"bibr9-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.12.1684"},{"key":"bibr10-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070040047029"},{"key":"bibr11-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9066-0"},{"key":"bibr12-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2584"},{"key":"bibr13-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.02.018"},{"key":"bibr14-ejo.5000166","first-page":"68","volume":"74","author":"Murata T.","year":"1996","journal-title":"Lab Invest"},{"key":"bibr15-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32832925f9"},{"key":"bibr16-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-007-0661-y"},{"key":"bibr17-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20070501-09"},{"key":"bibr18-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.140657"},{"key":"bibr19-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0786-7"},{"key":"bibr20-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318177f934"},{"key":"bibr21-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318159ec6b"},{"key":"bibr22-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1375-0"},{"key":"bibr23-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1678-9"},{"key":"bibr24-ejo.5000166","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007374"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5000166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:36:44Z","timestamp":1777405004000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5000166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,6]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.5301\/ejo.5000166"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5000166","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,6]]}}}