{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:58:37Z","timestamp":1777579117589,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,5,6]],"date-time":"2012-05-06T00:00:00Z","timestamp":1336262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Both intravitreal pegaptanib with laser therapy and intravitreal bevacizumab monotherapy have been found to be more efficacious than laser therapy alone in prospective, randomized, controlled clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The use of pegaptanib with laser therapy was efficacious in 91.2% compared with 69.0% in controls. The use of bevacizumab monotherapy was efficacious in 95.7% compared with 78.1% in controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of anti\u2013vascular endothelial growth factor therapy for retinopathy of prematurity has been shown to be efficacious, without toxicity reported to date; however, the best drug and dose which allows greatest efficacy with fewest recurrences and without toxicity must be determined.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000176","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T12:37:11Z","timestamp":1338899831000},"page":"685-686","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Intravitreal pegaptanib as adjunctive treatment for stage 3+ ROP shown to be effective in a prospective, randomized, controlled multicenter clinical trial"],"prefix":"10.1177","volume":"22","author":[{"given":"Helen A.","family":"Mintz-Hittner","sequence":"first","affiliation":[{"name":"Robert Cizik Eye Center, University of Texas Health Science Center at Houston Medical School, Department of Ophthalmology and Visual Science, Houston, TX - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,5,6]]},"reference":[{"key":"bibr1-ejo.5000176","first-page":"22","author":"Autrata R.","year":"2012","journal-title":"Eur J Ophthalmol"},{"key":"bibr2-ejo.5000176","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1056\/NEJMoa1007374","volume":"364","author":"Mintz-Hittner H.A.","year":"2011","journal-title":"N Engl J Med"},{"key":"bibr3-ejo.5000176","author":"Hu J.","year":"2012","journal-title":"Arch Ophthalmol Epub"},{"key":"bibr4-ejo.5000176","first-page":"96","volume":"108","author":"Hartnett M.E.","year":"2010","journal-title":"Trans Am Ophthalmol Soc"},{"key":"bibr5-ejo.5000176","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ajo.2011.07.005","volume":"153","author":"Sato T.","year":"2012","journal-title":"Am J Ophthalmol"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5000176","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:36:45Z","timestamp":1777405005000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5000176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,6]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.5301\/ejo.5000176"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5000176","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,6]]}}}