{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:23:35Z","timestamp":1778937815681,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>In addition to its proinflammatory effects, interleukin (IL)\u20136 also possesses antiapoptotic properties. Recently, IL-6 has been reported to protect retinal ganglion cells from pressure-induced apoptosis, indicating a possible role in the pathogenesis of primary open-angle glaucoma (POAG). A common polymorphism in the promoter region of IL-6 gene at position -174 characterized by a substitution from G to C has been found to decrease transcription rate of IL-6. The aim of our study was to investigate a hypothesized association between IL-6-174G&gt;C polymorphism and POAG in Caucasian patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>The present case-control study comprised 191 unrelated patients with POAG and 191 control subjects, matched for age and sex. Genotyping of the IL-6-174G&gt;C polymorphism was done using polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Allelic frequencies and genotype distribution of IL-6-174G&gt;C did not significantly differ between patients with POAG and control subjects (p&gt;0.05). Presence of the IL-6-174C allele was associated with a nonsignificant odds ratio of 0.78 (95% confidence interval 0.46\u20131.32; p=0.78) for POAG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Our findings suggest that the functional IL-6-174G&gt;C polymorphism itself is unlikely a major risk factor for POAG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000213","type":"journal-article","created":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T08:51:30Z","timestamp":1352451090000},"page":"183-186","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Role of Interleukin 6\u2013174G&gt;C Polymorphism in Primary Open-Angle Glaucoma"],"prefix":"10.1177","volume":"23","author":[{"given":"Christina","family":"Zimmermann","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Medical University of Graz, Graz - Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Weger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical University of Graz, Graz - Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Faschinger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical University of Graz, Graz - Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfried","family":"Renner","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz - Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Mossb\u00f6ck","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical University of Graz, Graz - Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,9,11]]},"reference":[{"key":"bibr1-ejo.5000213","first-page":"844","volume":"82","author":"Resnikoff S.","year":"2004","journal-title":"Bull World Health Organ"},{"key":"bibr2-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16257-0"},{"key":"bibr3-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1007\/BF02740665"},{"key":"bibr4-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60434-9"},{"key":"bibr5-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.797"},{"key":"bibr6-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1042\/bj3000281"},{"key":"bibr7-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.03.030"},{"key":"bibr8-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306178101"},{"key":"bibr9-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90046-A"},{"key":"bibr10-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19990215)55:4<411::AID-JNR2>3.0.CO;2-D"},{"key":"bibr11-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2004.06.014"},{"key":"bibr12-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1407"},{"key":"bibr13-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1136(200010)32:1<42::AID-GLIA40>3.0.CO;2-3"},{"key":"bibr14-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5317"},{"key":"bibr15-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2004.07.006"},{"key":"bibr16-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2629"},{"key":"bibr17-ejo.5000213","first-page":"1083","volume":"18","author":"Gibson J.","year":"2012","journal-title":"Mol Vis"},{"key":"bibr18-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.1.1.1"},{"key":"bibr19-ejo.5000213","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.5.1300"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5000213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:37:03Z","timestamp":1777405023000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5000213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,11]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.5301\/ejo.5000213"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5000213","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,11]]}}}