{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:39:13Z","timestamp":1790030353701,"version":"4.0.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T00:00:00Z","timestamp":1363737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To analyze results of amniotic membrane transplantation (AMT) in treatment of corneal ulceration after severe chemical and thermal injuries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Analysis of 55 AMT in 53 patients (53 eyes) with corneal ulceration and limbal deficiency 180\u2013360\u00b0 of the limbus after grade 4\u20136 (Dua classification, 2001) chemical and thermal injuries was performed. Mean terms of the operation were 46.1 \u00b1 46.4 days after the injury (range 8\u2013181 days). Preoperative visual acuity (VA) was &lt;0.01 in 33\/53 patients (62.3%). Mean follow-up period was 8.8 \u00b1 10.1 months (range 1.5\u201346 months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Further corneal ulceration was prevented in 54\/55 cases (98.1%), cornea epithelialized after 42\/55 AMT (76.3%). Mean terms of corneal epithelialization were 24.2 \u00b1 26.7 days after AMT (range 6\u2013123 days). Corneal defect recurred in 3\/42 successful cases (7.1%). Limbal deficiency of different extent with subsequent corneal conjunctivalization developed in all successful patients. The VA was \u22650.01 (range 0.01\u20131.0) in 23\/42 patients (54.8%) with corneal epithelialization. The VA at the last visit was improved on 2 and more lines on the eye chart compared to preoperative VA in 15\/42 patients with corneal epithelialization (35.7%), did not change in 18\/42 successful patients (42.9%), and decreased on one line in 9\/42 of these patients (26.2%). Symblepharon developed in 23\/42 successful patients (54.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Amniotic membrane transplantation may stop ulceration and promote corneal epithelialization in the majority of patients with the most severe chemical or thermal eye injuries in case of timely application of the operation and adequate fixation of the AMT graft.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000243","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T13:12:35Z","timestamp":1364476355000},"page":"496-503","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Amniotic Membrane Transplantation in Treatment of Persistent Corneal Ulceration after Severe Chemical and Thermal Eye Injuries"],"prefix":"10.1177","volume":"23","author":[{"given":"Stanislav A.","family":"Iakimenko","sequence":"first","affiliation":[{"name":"Department of Eye Burns, Ophthalmic Plastic Surgery, Keratoplasty and Keratoprosthesis, State Institution \u201cThe Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine,\u201d Odessa - Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksiy I.","family":"Buznyk","sequence":"additional","affiliation":[{"name":"Department of Eye Burns, Ophthalmic Plastic Surgery, Keratoplasty and Keratoprosthesis, State Institution \u201cThe Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine,\u201d Odessa - Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Rymgayllo-Jankowska","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Eye Hospital, Lublin - Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,3,20]]},"reference":[{"key":"bibr1-ejo.5000243","unstructured":"PuchkovskayaN.A., YakimenkoS.A., NepomyaschayaV.M. 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