{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:01:35Z","timestamp":1777579295969,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the association of serum vitamin D levels with exfoliation syndrome (XFS) and evaluate its impact on co-associated systemic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty patients with XFS and 40 control subjects without XFS were recruited for this study. Serum concentrations of 25-hydroxy vitamin D [25(OH) D] were measured by high-performance liquid chromatography. Vitamin D deficiency was defined as a serum 25(OH) D concentration of &lt;20 ng\/mL. A detailed medical history including hypertension, diabetes mellitus, ischemic heart disease, cerebrovascular stroke, autoimmune disease, and neurologic disorders such as Parkinson disease and Alzheimer disease was recorded. Student t test and chi-square test was used for statistical evaluations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age of patients with XFS and control subjects was 69.6 \u00b1 8.1 years (range 58\u201390 years) and 67.1 \u00b1 6.3 years (range 60\u201386 years), respectively (p&gt;0.05). Mean 25(OH) D levels did not differ between XFS (19.8 \u00b1 8.3 ng\/mL) and control (19.9 \u00b1 10.3 ng\/mL) groups (p = 0.978). Patients with XFS had higher prevalence of cerebrovascular (p = 0.026) and cardiovascular disease (p = 0.001). There was no association between the systemic disease status and serum vitamin D levels of patients with XFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although vitamin D levels were similar between XFS and control subjects, the levels were found to be decreased in both groups. Patients with XFS had a significantly higher prevalence of cerebrovascular and cardiovascular disease as compared to controls independent of their serum 25(OH) D levels. Low vitamin D level does not appear to be linked to XFS in the studied population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000246","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T04:56:52Z","timestamp":1371185812000},"page":"526-531","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Serum Vitamin D Deficiency and its Association with Systemic Disease in Exfoliation Syndrome"],"prefix":"10.1177","volume":"23","author":[{"given":"Sibel","family":"Kocabeyoglu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hacettepe University School of Medicine, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Cem","family":"Mocan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hacettepe University School of Medicine, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Irkec","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hacettepe University School of Medicine, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asli","family":"Pinar","sequence":"additional","affiliation":[{"name":"Central Laboratory Biochemistry Unit, Hacettepe University Hospitals, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Selcuk University, Selcuklu Medical Faculty, Konya - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hacettepe University School of Medicine, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,8,4]]},"reference":[{"key":"bibr1-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.08.012"},{"key":"bibr2-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080240092038"},{"key":"bibr3-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080240097039"},{"key":"bibr4-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70908-0"},{"key":"bibr5-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1159\/000090578"},{"key":"bibr6-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.01.047"},{"key":"bibr7-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.08.008"},{"key":"bibr8-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004-0002"},{"key":"bibr9-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000397894.02150.5f"},{"key":"bibr10-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)96020-1"},{"key":"bibr11-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.790314.x"},{"key":"bibr12-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(00)00196-X"},{"key":"bibr13-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1580"},{"key":"bibr14-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1177\/112067210801800408"},{"key":"bibr15-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702992"},{"key":"bibr16-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1111\/j.1395-3907.2004.00297.x"},{"key":"bibr17-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.01122.x"},{"key":"bibr18-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.6.702"},{"key":"bibr19-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2010.175"},{"key":"bibr20-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2012.02439.x"},{"key":"bibr21-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181d9d8bd"},{"key":"bibr22-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.11.1159"},{"key":"bibr23-ejo.5000246","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601952"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5000246","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:37:12Z","timestamp":1777405032000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5000246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.5301\/ejo.5000246"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5000246","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}