{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:54:46Z","timestamp":1791453286352,"version":"4.3.3"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T00:00:00Z","timestamp":1366243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare 2 different application methods of mitomycin C (MMC) in patients undergoing trabeculectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective trial compared outcomes of 191 eyes that underwent trabeculectomy with small-area (96 eyes; 50.3%) and large-area (95 eyes; 49.7%) MMC application. Main outcome measures were changes in intraocular pressure (IOP), required glaucoma medications, the frequency of complications, and postsurgical interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Within both treatment groups, a highly significant IOP reduction was seen during follow-up (p &lt; 0.0001). Statistical analyses revealed a significant difference in IOP between both groups. Patients treated with a larger size of surface area had a higher IOP reduction within the first postoperative year. Choroidal detachment, shallow anterior chamber, and bleb leak were seen more often in the large-area group with more aggressive MMC use. In contrast, complications associated with bleb failure such as bleb scarring were higher in the small-area group. Success rate was higher in the large-area MMC application group after 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Large-area treatment seems to be a more efficient application method of MMC during trabeculectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000287","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T04:06:52Z","timestamp":1375416412000},"page":"670-677","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Large-area versus Small-area Application of Mitomycin C during Trabeculectomy"],"prefix":"10.1177","volume":"23","author":[{"given":"Juliane","family":"Matlach","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Wuerzburg, Wuerzburg - Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermioni","family":"Panidou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Wuerzburg, Wuerzburg - Germany"},{"name":"Maximilians-Augenklinik, Nuremberg - Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Grehn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Wuerzburg, Wuerzburg - Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Klink","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Wuerzburg, Wuerzburg - Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,4,18]]},"reference":[{"key":"bibr1-ejo.5000287","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0002-9394(68)91288-9","volume":"66","author":"Cairns 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