{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:39:52Z","timestamp":1784723992470,"version":"3.55.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T00:00:00Z","timestamp":1368057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To determine the prevalence of cytomegalovirus retinitis (CMVR) and other fundus lesions in subjects with acquired immunodeficiency syndrome (AIDS) before and after the introduction of highly active antiretroviral therapy (HAART) in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The retrospective study included subjects with AIDS who consecutively attended a third referral center in Beijing before and after HAART was introduced. Comprehensive systemic and ophthalmic examinations, including CD4+ T-cell count, ophthalmoscopy, and fundus photography, were carried out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 173 HIV-infected, HAART-naive individuals and 267 people undergoing HAART were included in the study. The HAART-naive group as compared with the HAART group was significantly older (39.5 \u00b1 11.5 years versus 36.7 \u00b1 11.2 years; p = 0.02) and included significantly more men (p = 0.045). Prevalence of CMVR, microvascular retinopathy, and optic neuropathy in the HAART group (9.0 \u00b1 1.8%, 7.9 \u00b1 1.7%, and 4.9 \u00b1 1.3%, respectively) were significantly (all p\u22640.001) lower than in the HAART-naive group (20.2 \u00b1 3.1%, 31.2 \u00b1 3.5%, and 13.9 \u00b1 2.6%, respectively). Microvascular retinopathy was significantly associated with HAART-naive status (p&lt;0.001; odds ratio [OR] 0.20; 95% confidence interval [CI] 0.12, 0.36) and higher age (p = 0.002; OR 1.04; 95% CI 1.10, 1.06). Cytomegalovirus retinitis was significantly associated with CD4+ cell count &lt;50 cells\/\u03bcL (p = 0.001; OR 5.50; 95% CI 1.95, 15.5), HAART-naive status (p = 0.02; OR 0.23; 95% CI 0.07, 0.79), and lower best-corrected visual acuity (p&lt;0.001; OR 5.44; 95% CI 2.11, 14.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>As in Western countries, prevalence of CMVR and microvascular retinopathy in Chinese subjects with AIDS were significantly associated with a low CD4+ cell count and a HAART-naive status as the 2 major risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000354","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T06:17:17Z","timestamp":1391062637000},"page":"209-215","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Cytomegalovirus Retinitis in Patients with AIDS before and after Introduction of HAART in China"],"prefix":"10.1177","volume":"24","author":[{"given":"Hui Yu","family":"Sun","sequence":"first","affiliation":[{"name":"Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing - China"},{"name":"Department of Ophthalmology, Beijing Di Tan Hospital, Capital Medical University, Beijing - China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Yan","family":"Peng","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology, 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jost B.","family":"Jonas","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing - China"},{"name":"Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Heidelberg - Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,5,9]]},"reference":[{"key":"bibr1-ejo.5000354","unstructured":"UNAIDS. 2011 World AIDS Day report Available at: http:\/\/www.unaids.org\/en\/resources\/publications\/2011\/name,63525,en.asp Accessed October24, 2012."},{"key":"bibr2-ejo.5000354","unstructured":"The Epidemic of AIDS in China 2011 Available at: http:\/\/www.unaids.org.cn\/pics\/20130521161757.pdf Accessed August28th, 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