{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:47:03Z","timestamp":1778546823308,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T00:00:00Z","timestamp":1391040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To evaluate total plasma homocysteine (HCY) during fasting and post methionine load test (MLT), serum folate, serum vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      , and methylenetetrahydrofolate reductase (MTHFR) mutation in patients with retinal vein occlusion (RVO) and to examine the association between these risk factors and 2 subtypes of RVO: central (CRVO) and branch (BRVO).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This case-control study included 91 Italian patients presenting a first RVO and 71 healthy subjects, matched by age, without history of thromboembolic diseases, glaucoma, or malignancy. Homocysteine fasting and after MLT, serum folate level, serum vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      level, and other laboratory tests were assessed. Genetic analysis for the C677T MTHFR mutation was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariate logistic regression analysis indicated that hypertension (odds ratio [OR] 2.63; 95% confidence interval [CI] 1.30-5.30; p = 0.007), higher values of fasting HCY (OR 1.16; 95% CI 1.01-1.33; p = 0.03), and low concentrations of vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      (OR 0.99; 95% CI 0.995-0.999; p = 0.01) were independently correlated with RVO. Moreover, the main determinants for CRVO risk were hypertension (OR 2.46; 95% CI 1.06-5.72; p = 0.04), high values of fasting HCY (OR 1.20; 95% CI 1.02-1.41; p = 0.03), and low concentrations of vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      (OR 0.99; 95% CI 0.994-0.999; p = 0.008), whereas for BRVO risk only hypertension was significant (OR 2.74; 95% CI 1.24-6.03; p = 0.01). Genotype distribution of the MTHFR C677T mutation did not reveal any significant difference between patients and controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These results suggest that elevated fasting HCY levels, low vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      levels, and hypertension are associated with a risk of RVO, especially for CRVO. Moreover, our data suggest that only hypertension is associated with BRVO risk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000426","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T08:51:26Z","timestamp":1399625486000},"page":"735-743","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Plasma Homocysteine in Patients with Retinal Vein Occlusion"],"prefix":"10.1177","volume":"24","author":[{"given":"Giuseppe","family":"Minniti","sequence":"first","affiliation":[{"name":"DINOGMI, Laboratory of Metabolic Diseases, University of Genova, Istituto Giannina Gaslini, Genova - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Calevo","sequence":"additional","affiliation":[{"name":"Epidemiology, Biostatistics and Committee's Unit, Istituto Giannina Gaslini, Genova - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Giannattasio","sequence":"additional","affiliation":[{"name":"University of Genova, Istituto Giannina Gaslini, Genova - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Camicione","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Istituto Giannina Gaslini, Genova - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugo","family":"Armani","sequence":"additional","affiliation":[{"name":"Research Centre on Thrombosis and Atherosclerosis, Department of Internal Medicine, University of Genova, Genova - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Lorini","sequence":"additional","affiliation":[{"name":"University of Genova, Istituto Giannina Gaslini, Genova - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianna","family":"Piana","sequence":"additional","affiliation":[{"name":"Research Centre on Thrombosis and Atherosclerosis, Department of Internal Medicine, University of Genova, Genova - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,30]]},"reference":[{"key":"bibr1-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00709-1"},{"key":"bibr2-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.1.43"},{"key":"bibr3-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000165142.37711.E7"},{"key":"bibr4-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00923-X"},{"key":"bibr5-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1177\/1076029606296423"},{"key":"bibr6-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.03.039"},{"key":"bibr7-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-002-0431-9"},{"key":"bibr8-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2000.078003340.x"},{"key":"bibr9-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.5.812"},{"key":"bibr10-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S116"},{"key":"bibr11-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(98)90027-0"},{"key":"bibr12-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540460039030"},{"key":"bibr13-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198512123132404"},{"key":"bibr14-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(98)00812-7"},{"key":"bibr15-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.2.154"},{"key":"bibr16-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00476-6"},{"key":"bibr17-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2000.148"},{"key":"bibr18-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.08.028"},{"key":"bibr19-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1177\/1076029609348644"},{"key":"bibr20-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00571-3"},{"key":"bibr21-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.2.271"},{"key":"bibr22-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613137"},{"key":"bibr23-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(03)00293-7"},{"key":"bibr24-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.02.033"},{"key":"bibr25-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-11-0768"},{"key":"bibr26-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060900"},{"key":"bibr27-ejo.5000426","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.5.726"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5000426","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:37:49Z","timestamp":1777405069000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5000426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,30]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.5301\/ejo.5000426"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5000426","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,30]]}}}