{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:08:14Z","timestamp":1777579694969,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T00:00:00Z","timestamp":1415923200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Retinopathy of prematurity (ROP) is a leading cause of visual loss in infancy that is largely preventable with careful screening. We report the safety and efficacy of the use of phenylephrine 2.5% and cyclopentolate 0.5% eyedrops instilled 3 times 5 minutes apart in ROP screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1246 ROP screening eye examinations were carried out by the same pediatric ophthalmologist between February 2011 and May 2013. Outcome measures were successful mydriasis (defined as achieving a full screening examination) and any intraprocedural systemic complications (defined as any respiratory, cardiac, or other clinical deterioration severe enough to result in screening abandonment).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1246 eyes, 1234 (98.8%) achieved successful dilation to enable complete screening. A fourth application was successful in the remaining 1.2%. No respiratory or cardiac arrest or any other intraprocedural event requiring cessation of screening was encountered during any of the examinations. No retinal bleeding or other intraocular complication occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the largest cohort studying the effectiveness and safety of a mydriatic regimen for ROP screening. We have found the combination of phenylephrine 2.5% with cyclopentolate 0.5% to be efficacious and well-tolerated. The absence of any severe intraprocedural complications may be related to reduced indentation time and stress in the infant facilitated by effective pupil dilation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000540","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T05:47:55Z","timestamp":1417499275000},"page":"249-253","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Efficacy and Safety of Phenylephrine 2.5% with Cyclopentolate 0.5% for Retinopathy of Prematurity Screening in 1246 Eye Examinations"],"prefix":"10.1177","volume":"25","author":[{"given":"James E","family":"Neffendorf","sequence":"first","affiliation":[{"name":"Royal Berkshire Hospital, Reading and King Edward VII Hospital, Windsor - UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Michael","family":"Mota","sequence":"additional","affiliation":[{"name":"Royal Berkshire Hospital, Reading and King Edward VII Hospital, Windsor - UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanmin","family":"Xue","sequence":"additional","affiliation":[{"name":"Royal Berkshire Hospital, Reading and King Edward VII Hospital, Windsor - UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Darius","family":"Hildebrand","sequence":"additional","affiliation":[{"name":"Royal Berkshire Hospital, Reading and King Edward VII Hospital, Windsor - UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,11,14]]},"reference":[{"key":"bibr1-ejo.5000540","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300093"},{"key":"bibr2-ejo.5000540","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14631-4"},{"key":"bibr3-ejo.5000540","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090190051021"},{"key":"bibr4-ejo.5000540","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1413"},{"key":"bibr5-ejo.5000540","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(91)32074-8"},{"key":"bibr6-ejo.5000540","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20050501-05"},{"key":"bibr7-ejo.5000540","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2012.02.017"},{"issue":"4","key":"bibr8-ejo.5000540","first-page":"S1","volume":"95","author":"Phamonvaechavan P","year":"2012","journal-title":"J Med Assoc Thai"},{"key":"bibr9-ejo.5000540","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.77.6.364"},{"key":"bibr10-ejo.5000540","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0b013e318225a332"},{"key":"bibr11-ejo.5000540","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.5.425"},{"key":"bibr12-ejo.5000540","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80134-9"},{"key":"bibr13-ejo.5000540","first-page":"417","volume":"37","author":"Nair AK","year":"2000","journal-title":"Indian Pediatr"},{"key":"bibr14-ejo.5000540","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2003.00144.x"},{"key":"bibr15-ejo.5000540","unstructured":"Guideline for the Screening and Treatment of Retinopathy of Prematurity. 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