{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:30:26Z","timestamp":1777908626774,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,1,12]],"date-time":"2014-01-12T00:00:00Z","timestamp":1389484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of repeat trabeculectomy with risk factor\u2013adjusted mitomycin C (MMC) application in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG) over 2 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 58 patients (43 with POAG, 15 with PEXG) who had undergone repeat trabeculectomy with MMC were included in this retrospective study. Exposure time of MMC 0.3 mg\/mL was adjusted according to a standardized protocol. Main outcome measures were best-corrected visual acuity (BCVA), intraocular pressure (IOP) reduction, surgical success rate (criteria were defined as A: IOP \u226421 mm Hg and a reduction of IOP \u226520%; B: IOP \u226418 mm Hg and a reduction of IOP of \u226530%; C: IOP \u226415 mm Hg and a reduction of IOP of \u226540% from baseline), and number of medications at baseline, 3 months, and 2 years postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The BCVA remained stable for 2 years after surgery (0.47 \u00b1 0.47 at baseline, 0.49 \u00b1 0.64 logMAR units after 2 years, respectively). Mean IOP decreased from 22.2 \u00b1 7.0 mm Hg at baseline to 12.7 \u00b1 3.1 mm Hg at 3 months and 12.9 \u00b1 4.3 mm Hg 2 years after surgery. The qualified success rate for criterion A was 75.4%, for criterion B 66.6%, and for criterion C45.6%. Complete success rates were 42.9%, 37.5%, and 32.1%, respectively. Two years after repeat trabeculectomy, the mean IOP was reduced by 38.8%, and the number of medications was reduced significantly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Repeat trabeculectomy with MMC is successful at lowering IOP in POAG and PEXG and permits a significant and safe reduction of antiglaucomatous medication for at least 2 years after surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000542","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T05:47:55Z","timestamp":1417499275000},"page":"185-191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Two-Year Outcome of Repeat Trabeculectomy with Mitomycin C in Primary Open-Angle and PEX Glaucoma"],"prefix":"10.1177","volume":"25","author":[{"given":"Linda M.","family":"Meyer","sequence":"first","affiliation":[{"name":"Herzog Carl-Theodor Eye Clinic, Munich - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natascha E.","family":"Graf","sequence":"additional","affiliation":[{"name":"Herzog Carl-Theodor Eye Clinic, Munich - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Philipp","sequence":"additional","affiliation":[{"name":"Herzog Carl-Theodor Eye Clinic, Munich - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie T.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Herzog Carl-Theodor Eye Clinic, Munich - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Haller","sequence":"additional","affiliation":[{"name":"Herzog Carl-Theodor Eye Clinic, Munich - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Distelmaier","sequence":"additional","affiliation":[{"name":"Herzog Carl-Theodor Eye Clinic, Munich - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl-Ludwig","family":"Sch\u00f6nfeld","sequence":"additional","affiliation":[{"name":"Herzog Carl-Theodor Eye Clinic, Munich - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,12]]},"reference":[{"key":"bibr1-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.02.005"},{"key":"bibr2-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(87)90091-9"},{"key":"bibr3-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00045-2"},{"key":"bibr4-ejo.5000542","first-page":"81","volume":"3","author":"Lee SJ","year":"2009","journal-title":"Clin Ophthalmol"},{"key":"bibr5-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.9.1056"},{"key":"bibr6-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.01.062"},{"key":"bibr7-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-199904000-00006"},{"key":"bibr8-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(89)32888-0"},{"key":"bibr9-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01658-6"},{"key":"bibr10-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.6.686"},{"key":"bibr11-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12254"},{"key":"bibr12-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070130045027"},{"key":"bibr13-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00185-3"},{"key":"bibr14-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2011.25.6.401"},{"key":"bibr15-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.05.032"},{"key":"bibr16-ejo.5000542","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.10.026"},{"key":"bibr17-ejo.5000542","unstructured":"ShaarawyTM SherwoodMB GrehnF Guidelines on Design and Reporting of Glaucoma Surgical Trials. 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