{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T03:50:38Z","timestamp":1781236238962,"version":"3.54.1"},"reference-count":9,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report on a case of Histoplasma capsulatum endogenous endophthalmitis in an immunocompetent patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 30-year-old patient was admitted with floaters and vision impairment of 1 month's duration. He had a history of adrenal insufficiency, together with nasal, septum, and soft palate lesions of 3 months; duration. Culture results from specimens of these lesions were positive for H capsulatum. He was human immunodeficiency virus negative and there was no evidence of immunodepression or history of immunosuppression. Fundus examination revealed multiple fluffy balls with a string of pearls appearance, 2+ vitreous haze, multiple foci of retinochoroiditis inferiorly in the peripheral retina, and a 6-disk area lesion of retinochoroiditis at the superotemporal periphery. Due to poor response to oral itraconazole, a vitrectomy was performed with an intraocular injection of amphotericin B 5 \u03bcg\/0.1 mL and removal for a vitreous specimen for culture of bacteria and fungi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Vitreous specimen culture of the yeast at 28\u00b0C grew a white filamentous fungus colony, which was again cultured in a brain heart infusion agar medium, where it developed hyaline septate hyphae with microconidia and circular macroconidia with double wall, which was stained with a lactophenol dye at microscopic examination. The macroscopic morphology was consistent with H capsulatum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although endogenous H capsulatum endophthalmitis is a rare entity, it should be considered as a possible etiology even in apparently immunocompetent hosts, especially in patients with history of disseminated disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000550","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T05:47:19Z","timestamp":1421992039000},"page":"e53-e55","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Endogenous\n                    <i>Histoplasma Capsulatum<\/i>\n                    Endophthalmitis in An Immunocompetent Patient"],"prefix":"10.1177","volume":"25","author":[{"given":"Ariel","family":"Schlaen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hospital Universitario Austral, Buenos Aires - Argentina"},{"name":"Department of Ophthalmology, University of Buenos Aires, Buenos Aires - Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Ingolotti","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Universitario Austral, Buenos Aires - Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristobal","family":"Couto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Buenos Aires, Buenos Aires - Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nestor","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitario Austral, Buenos Aires - Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Pineda","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital Universitario Austral, Buenos Aires - Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Saravia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Universitario Austral, Buenos Aires - Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"bibr1-ejo.5000550","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00027-06"},{"key":"bibr2-ejo.5000550","first-page":"725","volume":"107","author":"Gonzales CA","year":"2000","journal-title":"capsulatum: a case report and literature review. Ophthalmology"},{"key":"bibr3-ejo.5000550","first-page":"45","volume":"90","author":"Klintworth GK","year":"1973","journal-title":"Histologic demonstration of Histoplasma capsulatum in choroidal lesions. Arch Ophthalmol"},{"key":"bibr4-ejo.5000550","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(67)91296-2"},{"key":"bibr5-ejo.5000550","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32603-9"},{"key":"bibr6-ejo.5000550","doi-asserted-by":"publisher","DOI":"10.3129\/i09-196"},{"key":"bibr7-ejo.5000550","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2012.09.001"},{"key":"bibr8-ejo.5000550","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1983.01040010774016"},{"key":"bibr9-ejo.5000550","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-198101030-00022"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5000550","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:38:17Z","timestamp":1777405097000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5000550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,25]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.5301\/ejo.5000550"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5000550","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,25]]}}}