{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:08:21Z","timestamp":1777579701265,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T00:00:00Z","timestamp":1421280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Adult-onset asthma with periocular xanthogranuloma and adult-onset xanthogranuloma are 2 rare subtypes of non-Langerhans cell histiocytic disorder and much remains unknown regarding optimal treatment. The authors describe their experience in the management of these 2 disease subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective case series with histopathologically proven orbital xanthogranuloma over a period of 12 years. Clinical, imaging, and histopathologic features; associated systemic conditions; treatment modality; and outcome during follow-up of 6 adult patients who had adult-onset asthma with periocular xanthogranuloma and adult-onset xanthogranuloma were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The age range was 29-75 years (median 56 years). The duration of symptoms and signs varied from 10 months to 9 years. All patients had bilateral and asymmetric involvement. Palpebral swelling with yellow discoloration and upper eyelid ptosis were the most common signs. Adult-onset asthma was present in 2 patients. Imaging studies demonstrated ill-defined infiltrative lesions involving the preseptal area, lacrimal glands, extraocular muscles, retrobulbar fat, and optic nerves. The median follow-up was 50 months. Complete regression of all clinical signs was obtained at 8 months, whereas imaging findings disappeared at 18 months with treatment. No recurrence was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment consisting of debulking as much affected soft tissue as possible followed by a 3-day course of intravenous pulse methylprednisolone administration and then by oral prednisone for at least 6 months may provide adequate regression of the granulomas without recurrence and satisfactory cosmesis in patients with adult orbital xanthogranuloma with and without asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000555","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T05:47:19Z","timestamp":1421992039000},"page":"288-292","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Adult Orbital Xanthogranulomas: Clinical Features and Management"],"prefix":"10.1177","volume":"25","author":[{"given":"Hayyam","family":"Kiratli","sequence":"first","affiliation":[{"name":"Ocular Oncology Service, Department of Ophthalmology, Hacettepe University School of Medicine, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meltem","family":"Kili\u00e7","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service, Department of Ophthalmology, Hacettepe University School of Medicine, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ber\u00e7in","family":"Tarlan","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service, Department of Ophthalmology, Hacettepe University School of Medicine, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"S\u00f6ylemezo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hacettepe University School of Medicine, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,1,15]]},"reference":[{"key":"bibr1-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.5858\/133.12.1994"},{"key":"bibr2-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.085894"},{"key":"bibr3-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1097\/01.IOP.0000083642.15174.83"},{"key":"bibr4-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1097\/01.IOP.0000132177.20945.E9"},{"key":"bibr5-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1080\/01676830600666201"},{"key":"bibr6-ejo.5000555","first-page":"99","volume":"91","author":"Jakobiec FA","year":"1993","journal-title":"Trans Am Ophthalmol Soc"},{"key":"bibr7-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.75.11.680"},{"key":"bibr8-ejo.5000555","first-page":"69","volume":"103","author":"Elner VM","year":"2005","journal-title":"Trans Am Ophthalmol Soc"},{"key":"bibr9-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/103241"},{"key":"bibr10-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.109587"},{"key":"bibr11-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01726.x"},{"key":"bibr12-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e31827ae96a"},{"key":"bibr13-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2008.583"},{"key":"bibr14-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-561381"},{"key":"bibr15-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00469-9"},{"key":"bibr16-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3181e99c9b"},{"key":"bibr17-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.3.251"},{"key":"bibr18-ejo.5000555","first-page":"105","volume":"4","author":"Papagoras C","year":"2010","journal-title":"Clin Ophthalmol"},{"key":"bibr19-ejo.5000555","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.02.024"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5000555","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:38:17Z","timestamp":1777405097000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5000555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,15]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.5301\/ejo.5000555"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5000555","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,15]]}}}