{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:11:00Z","timestamp":1782439860587,"version":"3.54.5"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of the ultrasonic circular cyclo-coagulation procedure using high-intensity focused ultrasound by a miniaturized annular device containing 6 piezoceramic transducers in patients with refractory glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective interventional noncomparative study of 20 eyes of 20 patients with refractory glaucoma. All eyes were treated with 6 activated transducers operating at 21 MHz. Ultrasound biomicroscopy and a complete ophthalmic examination were performed before the procedure and at 1 day, 1 week, and 1, 3, 6, and 12 months after the procedure. Primary outcomes were surgical success (defined as intraocular pressure (IOP) reduction from baseline \u226520% and IOP &gt;5 mm Hg) at the last follow-up visit. Secondary outcomes were mean IOP at each follow-up visit compared to baseline, medication use, complications, and re-interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intraocular pressure was significantly reduced (p&lt;0.01) from a mean preoperative value of 36.4 \u00b1 5.7 mm Hg to a mean postoperative value of 22.5 \u00b1 10.3 mm Hg at 12 months. Four patients needed to be re-treated. The mean IOP reduction achieved was 38%. Surgical success was achieved in 13 of 20 eyes (65%). No major intraoperative or postoperative complications occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ultrasonic circular cyclo-coagulation using high-intensity focused ultrasound delivered by a circular miniaturized device containing 6 piezoceramic transducers is an effective and well-tolerated method to reduce IOP in patients with refractory glaucoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000620","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T06:24:45Z","timestamp":1431930285000},"page":"483-489","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["High-Intensity Focused Ultrasound Treatment in Refractory Glaucoma Patients: Results at 1 Year of Prospective Clinical Study"],"prefix":"10.1177","volume":"25","author":[{"given":"Shlomo","family":"Melamed","sequence":"first","affiliation":[{"name":"The Sam Rothberg Glaucoma Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer - Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Modi","family":"Goldenfeld","sequence":"additional","affiliation":[{"name":"The Sam Rothberg Glaucoma Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer - Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cotlear","sequence":"additional","affiliation":[{"name":"The Sam Rothberg Glaucoma Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer - Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Skaat","sequence":"additional","affiliation":[{"name":"The Sam Rothberg Glaucoma Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer - Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Moroz","sequence":"additional","affiliation":[{"name":"The Sam Rothberg Glaucoma Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer - Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"key":"bibr1-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2006.01241.x"},{"key":"bibr2-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30508-3"},{"key":"bibr3-ejo.5000620","first-page":"189","volume":"63","author":"De Roetth A.","year":"1965","journal-title":"Trans Am Ophthalmol Soc."},{"key":"bibr4-ejo.5000620","first-page":"526","volume":"24","author":"al-Ghamdi S.","year":"1993","journal-title":"Ophthalmic Surg."},{"key":"bibr5-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)31718-X"},{"key":"bibr6-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.4.501c"},{"key":"bibr7-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.5301\/EJO.2011.6326"},{"key":"bibr8-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.3928\/1542-8877-20050701-04"},{"key":"bibr9-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(85)34029-0"},{"key":"bibr10-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(85)34028-9"},{"key":"bibr11-ejo.5000620","first-page":"186","volume":"20","author":"Maskin S.L.","year":"1989","journal-title":"Ophthalmic Surg."},{"key":"bibr12-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1007\/BF00918000"},{"key":"bibr13-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(86)33672-8"},{"key":"bibr14-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-5135"},{"key":"bibr15-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2011.01.017"},{"key":"bibr16-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8137"},{"key":"bibr17-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2012.665566"},{"key":"bibr18-ejo.5000620","volume-title":"Guidelines on Design and Reporting of Glaucoma Surgical Trials.","author":"Shaarawy T.","year":"2009"},{"key":"bibr19-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0280-z"},{"key":"bibr20-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2006.01241.x"},{"key":"bibr21-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01354.x"},{"key":"bibr22-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.116533"},{"key":"bibr23-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.45502"},{"key":"bibr24-ejo.5000620","author":"Denis P.","year":"2013","journal-title":"Ultrasonic circular cyclocoagulation in patients with primary open-angle glaucoma: a multicenter clinical trial."},{"key":"bibr25-ejo.5000620","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-8348-9_11"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000620","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5000620","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:39:50Z","timestamp":1777405190000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5000620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,13]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.5301\/ejo.5000620"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5000620","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,13]]}}}