{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:15:11Z","timestamp":1777580111663,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T00:00:00Z","timestamp":1436227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate corneal clarity quantitatively by corneal densitometry measurement in treatment-naive keratoconus patients and to compare these results with those of healthy control subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Corneal densitometry measurement of consecutive treatment-naive keratoconus patients and healthy control subjects was performed by Scheimpflug corneal topography (Pentacam\n                      <jats:sup>\u00ae<\/jats:sup>\n                      HR). Corneal densitometry measurements were expressed in gray scale unit (GSU) and the data from the right eyes of subjects were used for statistical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 102 subjects (51 patients with keratoconus [27 male, 24 female] and 51 healthy control subjects [24 male, 27 female]) were included in the study. There was no statistically significant difference with regard to the mean age (p = 0.910) or distribution of sex (p = 0.552) between the groups. There were significant differences in corneal densitometry values of the groups in central 2 mm (17.95 \u00b1 0.33 GSU in keratoconus and 16.43 \u00b1 0.24 GSU in controls, p&lt;0.001) and in annulus of 2 to 6 mm in diameter (15.88 \u00b1 0.26 GSU in keratoconus and 15.02 \u00b1 0.22 GSU in controls, p = 0.015). When considering the measurements in different depths, the anterior layer displayed the highest densitometry value compared to that of both the central and posterior layers. Corneal densitometry of anterior 0-2 mm was positively correlated with simulated K value (r = 0.446, p = 0.001), whereas it was negatively correlated with central corneal thickness (r = \u22120.361, p = 0.016) in keratoconus patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment-naive keratoconus patients have significantly higher corneal densitometry values in central cornea when compared to healthy control subjects. The clinical relevance should be further studied in detail.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000644","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T05:46:24Z","timestamp":1436766384000},"page":"18-23","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Quantitative Assessment of Corneal Clarity in Keratoconus: A Case Control Study of Corneal Densitometry"],"prefix":"10.1177","volume":"26","author":[{"given":"Mustafa Alpaslan","family":"Anayol","sequence":"first","affiliation":[{"name":"Ulucanlar Eye Training and Research Hospital, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Ali","family":"Sekeroglu","sequence":"additional","affiliation":[{"name":"Ulucanlar Eye Training and Research Hospital, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basak Bostanci","family":"Ceran","sequence":"additional","affiliation":[{"name":"Ulucanlar Eye Training and Research Hospital, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmethan","family":"Dogan","sequence":"additional","affiliation":[{"name":"Ulucanlar Eye Training and Research Hospital, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suleyman","family":"Gunaydin","sequence":"additional","affiliation":[{"name":"Ulucanlar Eye Training and Research Hospital, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pelin","family":"Yilmazbas","sequence":"additional","affiliation":[{"name":"Ulucanlar Eye Training and Research Hospital, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,7,7]]},"reference":[{"key":"bibr1-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.278"},{"key":"bibr2-ejo.5000644","first-page":"2019","volume":"7","author":"Vazirani J","year":"2013","journal-title":"Clin Ophthalmol"},{"key":"bibr3-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2005.12.092"},{"key":"bibr4-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e31821ffbd4"},{"key":"bibr5-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200203000-00017"},{"key":"bibr6-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2004.00805.x"},{"key":"bibr7-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e3283511b42"},{"key":"bibr8-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2010.24.5.284"},{"key":"bibr9-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.08.024"},{"key":"bibr10-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-302913"},{"key":"bibr11-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.03.018"},{"key":"bibr12-ejo.5000644","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s00347-013-2962-3","volume":"111","author":"B\u00fchren J","year":"2014","journal-title":"Ophthalmologe"},{"key":"bibr13-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.08.061"},{"key":"bibr14-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304132"},{"key":"bibr15-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20100618-02"},{"key":"bibr16-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-013-9736-4"},{"key":"bibr17-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.06.067"},{"key":"bibr18-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2012.07.041"},{"key":"bibr19-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2011.03.037"},{"key":"bibr20-ejo.5000644","first-page":"81","volume":"23","author":"Olsen T","year":"1982","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr21-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13236"},{"key":"bibr22-ejo.5000644","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000266"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5000644","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:39:56Z","timestamp":1777405196000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5000644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,7]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.5301\/ejo.5000644"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5000644","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,7]]}}}