{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:15:19Z","timestamp":1777580119128,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To establish normal values for retinal nerve fiber layer (RNFL), macular thickness, and macular volume in children using spectral-domain optical coherence tomography (OCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A descriptive cross-sectional study was performed in healthy children between 3 and 14 years of age. Each child underwent a comprehensive ophthalmic examination that included 3 OCT scans with Spectralis (Heidelberg Engineering, Heidelberg, Germany). All measurements were performed by the same operator, and one eye was randomly selected. The influence of age, sex, and refraction on OCT measurements was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sample consisted of 162 Caucasian subjects, mean age 8.1 \u00b1 3.03 years. The spherical equivalent was 0.03 \u00b1 0.19 D (range \u00b14 D, astigmatism &lt;1 D). The average values were 263.69 \u00b1 4.54 \u00b5m for central macular thickness, 0.21 \u00b1 0.01 mm\n                      <jats:sup>3<\/jats:sup>\n                      for central macular volume, and 100.45 \u00b1 1.98 \u00b5m for RNFL. A significant correlation between RNFL and spherical equivalent was found for the nasal (p = 0.001), inferior (p = 0.009), and inferior nasal (p = 0.005) sectors. No differences were found with regard to sex (p&gt;0.05). However, central macular thickness and central macular volume were correlated with age (p = 0.027, p = 0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides reference values for macular thickness, macular volume, and RNFL in healthy children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000665","type":"journal-article","created":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T07:30:38Z","timestamp":1443771038000},"page":"135-141","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Study of Spectral-Domain Optical Coherence Tomography in Children: Normal Values and Influence of Age, Sex, and Refractive Status"],"prefix":"10.1177","volume":"26","author":[{"given":"Diana","family":"P\u00e9rez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, \u201cLozano Blesa\u201d University Hospital, Zaragoza - Spain"},{"name":"IIS Aragon, Aragon Health Sciences Institute, Zaragoza - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Iba\u00f1ez-Alperte","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, \u201cLozano Blesa\u201d University Hospital, Zaragoza - Spain"},{"name":"IIS Aragon, Aragon Health Sciences Institute, Zaragoza - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le\u00f3n","family":"Rem\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, \u201cLozano Blesa\u201d University Hospital, Zaragoza - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 \u00c1ngel","family":"Crist\u00f3bal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, \u201cLozano Blesa\u201d University Hospital, Zaragoza - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Sanchez-Cano","sequence":"additional","affiliation":[{"name":"IIS Aragon, Aragon Health Sciences Institute, Zaragoza - Spain"},{"name":"Department of Applied Physics, University of Zaragoza, Zaragoza - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Pinilla","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, \u201cLozano Blesa\u201d University Hospital, Zaragoza - Spain"},{"name":"IIS Aragon, Aragon Health Sciences Institute, Zaragoza - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"bibr1-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0b013e318187e801"},{"key":"bibr2-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181a98cfa"},{"key":"bibr3-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30512-5"},{"key":"bibr4-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)93601-6"},{"key":"bibr5-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)31032-9"},{"key":"bibr6-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1126\/science.1957169"},{"key":"bibr7-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.3.002950"},{"key":"bibr8-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.08.010"},{"key":"bibr9-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.08.026"},{"key":"bibr10-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2012.02562.x"},{"key":"bibr11-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-300916"},{"key":"bibr12-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-012-0142-7"},{"key":"bibr13-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.08.037"},{"key":"bibr14-ejo.5000665","doi-asserted-by":"publisher","DOI":"10.1364\/OE.17.004221"},{"key":"bibr15-ejo.5000665","first-page":"1796","volume":"103","author":"Patz A","year":"1985","journal-title":"Early Treatment Diabetic Retinopathy Study report number 1. 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