{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:16:42Z","timestamp":1777580202935,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T00:00:00Z","timestamp":1463356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the anterior lamina cribrosa (LC) surface position in patients with idiopathic intracranial hypertension (IIH), primary open-angle glaucoma (high-tension glaucoma [HTG] and normal-tension glaucoma [NTG]), and healthy controls using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective, cross-sectional observational study of 11 eyes with IIH, 20 eyes with HTG, 20 eyes with NTG, and 37 control eyes. Serial horizontal B-scans of the optic nerve head were obtained using EDI-OCT. The LC depth, defined as the distance from the Bruch membrane opening plane to the anterior LC surface, was manually measured on selected B-scans covering the central three-quarters of the optic nerve head in each eye.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean LC depth in patients with IIH (325.2 \u00b1 92.1 \u00b5m) was significantly (p&lt;0.01) decreased compared to control subjects (387.8 \u00b1 53.9 \u00b5m). In HTG, the mean LC depth (493.0 \u00b1 115.2 \u00b5m) was significantly increased compared to NTG (376.6 \u00b1 27.1 \u00b5m, p&lt;0.05) and control subjects (332.7 \u00b1 53.1 \u00b5m, p&lt;0.001). The trans-LC pressure difference (TLPD) (intraocular pressure \u2212 cerebrospinal fluid pressure) was positively correlated with the LC depth (r = 0.96, p&lt;0.001) and inversely correlated with visual field perimetric mean deviation in patients with IIH (r = -0.88, p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The LC is positioned anteriorly in patients with IIH and posteriorly in glaucomatous eyes compared to normal controls. The positional changes of the LC could be a result of the TLPD between the intraocular and intracranial pressure compartments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000806","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T06:20:53Z","timestamp":1463466053000},"page":"55-61","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Anterior Lamina Cribrosa Surface Position in Idiopathic Intracranial Hypertension and Glaucoma"],"prefix":"10.1177","volume":"27","author":[{"given":"Jenni M.","family":"Villarruel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen - Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Q.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen - Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella","family":"Bach-Holm","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen - Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Hamann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen - Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,5,16]]},"reference":[{"key":"bibr1-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.31.9.551"},{"key":"bibr2-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-012-0207-4"},{"key":"bibr3-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2012.08.009"},{"key":"bibr4-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0b013e3182aabef4"},{"key":"bibr5-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(83)90389-6"},{"key":"bibr6-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.01-1282"},{"key":"bibr7-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0174"},{"key":"bibr8-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.06.001"},{"key":"bibr9-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.01.013"},{"key":"bibr10-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.01915.x"},{"key":"bibr11-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2228"},{"key":"bibr12-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.06.058"},{"key":"bibr13-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1657-1"},{"key":"bibr14-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11530"},{"key":"bibr15-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-13957"},{"key":"bibr16-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2011.02669.x"},{"key":"bibr17-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.12.008"},{"key":"bibr18-ejo.5000806","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305558"},{"key":"bibr19-ejo.5000806","unstructured":"Headache Classification Subcommittee of the International Headache Disorders. 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