{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:44:30Z","timestamp":1790034270320,"version":"4.0.1"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,7,16]],"date-time":"2016-07-16T00:00:00Z","timestamp":1468627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the efficiency of brinzolamide\/brimonidine fixed combination vs the dorzolamide\/timolol fixed combination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty-four eyes of 44 patients were divided in 2 groups treated either with dorzolamide\/timolol twice a day (group A) or with brinzolamide\/brimonidine twice a day (group B). Complete ophthalmic examination including Goldmann applanation tonometry was performed before treatment administration and 1, 4, 8, and 12 weeks afterwards. The intraocular pressure (IOP) was measured twice a day (morning at 9 AM and afternoon at 4 PM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the end of the follow-up period (12 weeks), mean morning IOP reduction was 7.0 \u00b1 2.8 mm Hg in group A and 8.4 \u00b1 1.9 mm Hg in group B. A significant difference was found (p = 0.0343). In contrast, mean afternoon IOP reduction was 8.6 \u00b1 2.7 mm Hg in group A and 7.9 \u00b1 1.6 mm Hg in group B and no significant difference was found (p = 0.3413). No significant adverse effects were observed in either group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Brinzolamide\/brimonidine seems to be an effective and safe alternative \u03b2-blocker free fixed combination, especially for patients with comorbidities, having its own antihypertensive profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000826","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T04:18:06Z","timestamp":1469420286000},"page":"160-163","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of Dorzolamide\/Timolol vs Brinzolamide\/Brimonidine Fixed Combination Therapy in the Management of Primary Open-Angle Glaucoma"],"prefix":"10.1177","volume":"27","author":[{"given":"Vassileios","family":"Kozobolis","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University General Hospital of Evros, Alexandroupolis - Greece"},{"name":"Eye Institute of Thrace, School of Medicine, University of Thrace, Alexandroupolis - Greece"},{"name":"Glaucoma Laser Eye Center, Athens - Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios D.","family":"Panos","sequence":"additional","affiliation":[{"name":"Eye Institute of Thrace, School of Medicine, University of Thrace, Alexandroupolis - Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristeidis","family":"Konstantinidis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University General Hospital of Evros, Alexandroupolis - Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Labiris","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University General Hospital of Evros, Alexandroupolis - Greece"},{"name":"Eye Institute of Thrace, School of Medicine, University of Thrace, Alexandroupolis - Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,16]]},"reference":[{"key":"bibr1-ejo.5000826","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2012.02.003"},{"key":"bibr2-ejo.5000826","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200059030-00003"},{"issue":"10","key":"bibr3-ejo.5000826","first-page":"1945","volume":"105","author":"Boyle JE","year":"1998","journal-title":"A randomized trial comparing the dorzolamide-timolol combination given twice daily to monotherapy with timolol and dorzolamide. 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