{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:16:36Z","timestamp":1777580196740,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:00:00Z","timestamp":1452211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The pathophysiologic pathways that govern the development of choroidal neovascularization (CNV) are complex. Patchy atrophy and lacquer cracks are known to be major anatomic risk factors for the development of myopic CNV, but they are not alone and much remains to be understood about other factors that influence development. In addition, a greater understanding of the modifiable and nonmodifiable factors that influence outcome, resolution, and recurrence after intravitreal injection of anti-vascular endothelial growth factor (VEGF) could lead to more personalized treatment algorithms that integrate parameters other than the presence of CNV itself and could help improve clinical outcomes and reduce recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed recently published data on risk factors for CNV and predictors of response to anti-VEGF treatments. In particular, data pertaining to age, sex, genetic predisposition, baseline visual acuity, axial length, staphyloma, lacquer cracks, atrophic lesions, choroidal thickness or choroidal thinning, characteristics of CNV such as duration, localization, and size of CNV, and treatment considerations such as choice of treatment, loading doses, and combination treatments were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our analysis showed that the body of evidence is incomplete.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Additional studies are required to identify high-risk patients and to develop personalized therapeutic approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000839","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T05:11:17Z","timestamp":1470978677000},"page":"511-516","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Understanding the Determinants of Myopic Choroidal Neovascularization and Response to Treatment"],"prefix":"10.1177","volume":"26","author":[{"given":"Nicolas","family":"Leveziel","sequence":"first","affiliation":[{"name":"Department of ophthalmology, CHU Poitiers, Poitiers - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gaucher","sequence":"additional","affiliation":[{"name":"New Civil Hospital, University Hospitals of Strasbourg, Strasbourg - France"},{"name":"Laboratory of Bacteriology (EA-7290), Federation of Medicine Translational of Strasbourg, University of Strasbourg, Strasbourg - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Baillif","sequence":"additional","affiliation":[{"name":"Ophtalmology Department, University Hospital of Saint Roch, University of Nice Sophia Antipolis, Nice - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Benouaich","sequence":"additional","affiliation":[{"name":"Clinic of Union, Union - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Chartier","sequence":"additional","affiliation":[{"name":"Novartis, Rueil-Malmaison - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thyphaine","family":"Grenet","sequence":"additional","affiliation":[{"name":"Ophthalmic Imaging and Laser Center, Paris - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Gualino","sequence":"additional","affiliation":[{"name":"Honor\u00e9 Cave Clinic, Montauban - France"},{"name":"Department of Ophthalmology, University Hospital of Lariboisi\u00e8re, Paris Hospitals, Paris - France"},{"name":"University Hospital of Toulouse, Purpan, Paule de Viguier, Toulouse - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Krivosic","sequence":"additional","affiliation":[{"name":"Private Clinic and University Hospital of Lariboisi\u00e8re, Paris Hospitals, Paris - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Noelle","family":"Delyfer","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology, University Hospital of Bordeaux, Bordeaux - France"},{"name":"Department of Ophthalmology, Pellegrin Hospital, Bordeaux - France"},{"name":"University of Bordeaux, France-INSERM, ISPED, INSERM Center U897-Epidemiology Biostatistics, Bordeaux - France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,1,8]]},"reference":[{"key":"bibr1-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199212020-00009"},{"key":"bibr2-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.5.570"},{"key":"bibr3-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.11.003"},{"key":"bibr4-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2012.04.001"},{"key":"bibr5-ejo.5000839","first-page":"2265","volume":"18","author":"Shin YJ","year":"2012","journal-title":"Mol Vis"},{"key":"bibr6-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.10.012"},{"key":"bibr7-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11542"},{"key":"bibr8-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318227aa09"},{"key":"bibr9-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.10.023"},{"key":"bibr10-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.06.010"},{"issue":"5","key":"bibr11-ejo.5000839","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0002-9394(01)00967-9","volume":"131","year":"2001","journal-title":"Am J Ophthalmol"},{"key":"bibr12-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-302973"},{"key":"bibr13-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.163535"},{"key":"bibr14-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.11.021"},{"key":"bibr15-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0324-4"},{"key":"bibr16-ejo.5000839","unstructured":"LevezielN Quaranta-El MaftouhibM LalloumcF SouiedE CohenSY J Fr Ophtalmol. 2014;37:320\u2013328"},{"key":"bibr17-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318285cc24"},{"key":"bibr18-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2010.226"},{"key":"bibr19-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-012-2159-5"},{"key":"bibr20-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.08.002"},{"key":"bibr21-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200208000-00004"},{"key":"bibr22-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00909.x"},{"key":"bibr23-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2012.0067"},{"key":"bibr24-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9538"},{"key":"bibr25-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12280"},{"key":"bibr26-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9405"},{"key":"bibr27-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.140"},{"key":"bibr28-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1038\/nature02168"},{"key":"bibr29-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.08.028"},{"key":"bibr30-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.06.043"},{"key":"bibr31-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3493"},{"key":"bibr32-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-012-2066-9"},{"key":"bibr33-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318214d094"},{"key":"bibr34-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-004-0960-5"},{"key":"bibr35-ejo.5000839","first-page":"67","volume":"75","author":"Curtin BJ","year":"1977","journal-title":"Trans Am Ophthalmol Soc"},{"key":"bibr36-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.03.010"},{"key":"bibr37-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71034-7"},{"key":"bibr38-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318174417a"},{"key":"bibr39-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318242b990"},{"key":"bibr40-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.04.018"},{"key":"bibr41-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318251a3a8"},{"key":"bibr42-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182278bae"},{"key":"bibr43-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.07.017"},{"key":"bibr44-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.97"},{"key":"bibr45-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31827d260a"},{"key":"bibr46-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6703052"},{"key":"bibr47-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-009-1285-1"},{"key":"bibr48-ejo.5000839","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.145391"},{"key":"bibr49-ejo.5000839","unstructured":"European Medicines Agency. Lucentis 10 mg\/ml solution for injection, summary of product characteristics. 2014 Available at http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/human\/000715\/WC500043546.pdf"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000839","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5000839","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5000839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:40:26Z","timestamp":1777405226000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5000839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,8]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.5301\/ejo.5000839"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5000839","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,8]]}}}