{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:51:16Z","timestamp":1793368276175,"version":"4.5.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2017,6,26]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the effect of intraoperative sub-Tenon injection of triamcinolone acetonide (TA) as an adjunct to Ahmed glaucoma valve (AGV) implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this triple-blind randomized clinical trial, 104 eyes with refractory glaucoma were randomly assigned to conventional AGV (non-TA group) or AGV with adjunctive triamcinolone (TA group). In the TA group, 10 mg TA was injected in the sub-Tenon space around the AGV plate intraoperatively. Patients were followed for 1 year. The main outcome measure was intraocular pressure (IOP). Other outcome measures included best-corrected visual acuity (BCVA), occurrence of hypertensive phase (HP), peak IOP, number of antiglaucoma medications, and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 90 patients were included in the final analysis. Mean IOP was lower in the TA group at most follow-up visits; however, the difference was statistically significant only at the first month (p = 0.004). Linear mixed model showed that mean IOP was 1.5 mm Hg lower in the TA group throughout the study period (p = 0.006). Peak postoperative IOP was significantly lower in the TA group (19.3 \u00b1 4.8 mm Hg versus 29 \u00b1 9.2 mm Hg, p = 0.032). Rates of success (defined as 6 &lt; IOP &lt;21 mm Hg) were similar in both groups at 12 months. There was no difference in the occurrence of the HP between the 2 groups (p = 0.123). Loss of BCVA &gt;2 lines was more common in the non-TA group (p = 0.032).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adjunctive intraoperative TA injection during AGV implantation can blunt peak IOP levels and reduce mean IOP up to 1 year. Visual outcomes also seem to be superior to standard surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000892","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T05:23:57Z","timestamp":1477632237000},"page":"411-416","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Adjunctive Triamcinolone Acetonide for Ahmed Glaucoma Valve Implantation: A Randomized Clinical Trial"],"prefix":"10.1177","volume":"27","author":[{"given":"Shahin","family":"Yazdani","sequence":"first","affiliation":[{"name":"Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran"},{"name":"Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Doozandeh","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Pakravan","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Ownagh","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Yaseri","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran - Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"key":"bibr1-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-199904000-00012"},{"key":"bibr2-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.05.004"},{"key":"bibr3-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)91049-1"},{"key":"bibr4-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00630-5"},{"key":"bibr5-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181e080ef"},{"key":"bibr6-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000256"},{"key":"bibr7-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.09.037"},{"key":"bibr8-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1177\/112067210501500105"},{"key":"bibr9-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12274"},{"key":"bibr10-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.03.014"},{"key":"bibr11-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S64257"},{"key":"bibr12-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.07.035"},{"key":"bibr13-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01969-3"},{"key":"bibr14-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e318294869b"},{"key":"bibr15-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10008-1159"},{"issue":"2","key":"bibr16-ejo.5000892","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3928\/1542-8877-20000301-05","volume":"31","author":"Kook MS","year":"2000","journal-title":"Ophthalmic Surg Lasers"},{"key":"bibr17-ejo.5000892","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.09.003"},{"issue":"11","key":"bibr18-ejo.5000892","first-page":"2275","volume":"121","author":"Sen HN","year":"2014","journal-title":"Periocular corticosteroid injections in uveitis: effects and complications. 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