{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:21:39Z","timestamp":1778631699201,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T00:00:00Z","timestamp":1484524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate choroidal thickness (CT) and its relationship with retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer thickness (GCIPLT) in glaucomatous, preperimetric glaucomatous, and healthy eyes using swept-source optical coherence tomography (SS-OCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty eyes with primary open-angle glaucoma, 20 eyes with preperimetric glaucoma, and 20 age-matched healthy eyes were enrolled. Three-dimensional wide-field (12 \u00d7 9 mm) images were obtained using a SS-OCT instrument. Peripapillary CT and RNFL thickness, as well as macular CT and GCIPLT, were recorded. The correlation of the CT with nerve fiber layer and GCIPLT measurements was assessed. The association between CT and potential confounding variables including age, sex, axial length, intraocular pressure, and central corneal thickness was also examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean peripapillary CTs were 111.7 \u00b1 41.7, 127.7 \u00b1 40.1, and 120.8 \u00b1 35.4 \u03bcm in glaucomatous, preperimetric glaucomatous, and normal eyes, respectively. There was statistically significant but weak correlation for the mean RNFL and mean peripapillary CT in glaucomatous subjects (r = 0.341, p = 0.04). There was a significant correlation between RNFL thickness and peripapillary CT in 1, 2, 5, and 6 clock hours of glaucomatous eyes (r = 0.410, p = 0.005; r = 0.316, p = 0.03; r = 0.346, p = 0.02; r = 0.35, p = 0.04, respectively). Mean macular CT was 181.5 \u00b1 70.5, 187.4 \u00b1 65.5, and 185.4 \u00b1 76.4 \u03bcm in glaucomatous, preperimetric glaucomatous, and healthy eyes, respectively (p = 0.7). There was no statistically significant correlation between the mean GCIPLT and mean macular CT in all subjects (p&gt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Choroidal thinning and its correlation with other parameters in patients with glaucoma should be further investigated with the proprietary software of SS-OCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5000926","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T06:13:28Z","timestamp":1484892808000},"page":"548-554","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Choroidal Thickness and Structural Glaucoma Parameters in Glaucomatous, Preperimetric Glaucomatous, and Healthy Eyes using Swept-Source OCT"],"prefix":"10.1177","volume":"27","author":[{"given":"Handan","family":"Akil","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayss","family":"Al-Sheikh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalil Ghasemi","family":"Falavarjani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Chopra","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,16]]},"reference":[{"key":"bibr1-ejo.5000926","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(98)00014-7"},{"key":"bibr2-ejo.5000926","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.10.1268"},{"key":"bibr3-ejo.5000926","doi-asserted-by":"publisher","DOI":"10.1007\/BF00159262"},{"key":"bibr4-ejo.5000926","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00008-3"},{"key":"bibr5-ejo.5000926","volume-title":"In: Kaufman PL, Alm A, eds Adler's Physiology of the Eye,","author":"Cioffi GA","edition":"10"},{"key":"bibr6-ejo.5000926","doi-asserted-by":"publisher","DOI":"10.1159\/000310179"},{"key":"bibr7-ejo.5000926","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8782"},{"key":"bibr8-ejo.5000926","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.05.037"},{"key":"bibr9-ejo.5000926","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000024"},{"issue":"7","key":"bibr10-ejo.5000926","first-page":"430","volume":"77","author":"Kubota T","year":"1993","journal-title":"An aetiological factor for deep retinal changes in glaucoma? 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