{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:39:48Z","timestamp":1790836788121,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"\n Purpose:<\/jats:title>\n To determine the effect of intravenous mannitol on globe and orbital volumes.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Retrospective chart review of a consecutive series of Cleveland Clinic Neurosurgical Intensive Care Unit patients who underwent computed tomographic imaging before and after intravenous mannitol administration. Volume measurements were performed according to a previously described technique by averaging axial image areas. Measurements before and after mannitol administration were compared using paired t-test.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Fourteen patients (28 eyes) met inclusion criteria. Average globe volume decreased 186 mm\n 3<\/jats:sup>\n (-2.5%, p = 0.02) after mannitol administration, while average orbital volume increased 353 mm\n 3<\/jats:sup>\n (+3.5%, p = 0.04). Average globe volume change for subjects with follow-up scan less than 4.7 hours (mean 1.9 hours; range 0.2-4.5 hours) after mannitol administration was -125 mm\n 3<\/jats:sup>\n (-1.7%, p = 0.24) and average orbital volume change was +458 mm\n 3<\/jats:sup>\n (+5.1%, p = 0.11). Average globe volume change after mannitol administration for those with follow-up more than 4.7 hours (average 13.9 hours, range 4.9-24.7 hours) was -246 mm\n 3<\/jats:sup>\n (-3.3%, p = 0.05) and orbital volume change was +248 mm\n 3<\/jats:sup>\n (+2.2%, p = 0.24). Dividing the study population into groups based on mannitol dose did not yield any statistically significant change.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Human globe volume decreases after intravenous mannitol administration, while orbital volume increases. These volume changes occur during the time period when intraocular pressure normalizes, after the pressure-lowering effects of the drug. This novel volumetric information improves our understanding of mannitol\u2019s mechanism of action and its effects on human ocular and periocular tissues.<\/jats:p>\n <\/jats:sec>","DOI":"10.5301\/ejo.5001008","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T07:16:17Z","timestamp":1501830977000},"page":"163-167","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of mannitol on globe and orbital volumes in humans"],"prefix":"10.1177","volume":"28","author":[{"given":"Adam C.","family":"Weber","sequence":"first","affiliation":[{"name":"Cullen Eye Institute, Baylor College of Medicine, Houston, Texas - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander D.","family":"Blandford","sequence":"additional","affiliation":[{"name":"Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan R.","family":"Costin","sequence":"additional","affiliation":[{"name":"Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian D.","family":"Perry","sequence":"additional","affiliation":[{"name":"Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,5,6]]},"reference":[{"key":"bibr1-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1963.00960050627008"},{"key":"bibr2-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-197606000-00002"},{"issue":"3","key":"bibr3-ejo.5001008","first-page":"189","volume-title":"Acta Neurochir (Wien)","volume":"36","author":"James HE","year":"1977"},{"issue":"3","key":"bibr4-ejo.5001008","first-page":"269","volume-title":"Neurosurgery","volume":"13","author":"McGraw CP","year":"1983"},{"key":"bibr5-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1969.00990020688019"},{"key":"bibr6-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.25.3.173.13474"},{"issue":"6","key":"bibr7-ejo.5001008","first-page":"418","volume":"9","author":"Kolker AE","year":"1970","journal-title":"Invest Ophthalmol"},{"key":"bibr8-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e3182417bc2"},{"key":"bibr9-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.61.4.0700"},{"issue":"5","key":"bibr10-ejo.5001008","first-page":"695","volume-title":"Arch Ophthalmol","volume":"81","author":"Barry KG","year":"1969"},{"issue":"12","key":"bibr11-ejo.5001008","first-page":"1392","volume":"13","author":"Quon DK","year":"1981","journal-title":"Ann Ophthalmol"},{"key":"bibr12-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2000.16.591"},{"key":"bibr13-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(73)90087-1"},{"issue":"1","key":"bibr14-ejo.5001008","first-page":"29","volume":"29","author":"Khosla PK","year":"1981","journal-title":"Indian J Ophthalmol"},{"key":"bibr15-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.145.1.149"},{"key":"bibr16-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5155(01)00419-1"},{"key":"bibr17-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.96.4.0742"},{"key":"bibr18-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e31829d028a"},{"key":"bibr19-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1097\/01.IOP.0000062848.26273.E5"},{"key":"bibr20-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.77.2.100"},{"key":"bibr21-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.8.618"},{"key":"bibr22-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.37.10.1105"},{"key":"bibr23-ejo.5001008","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3181b80c6a"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5001008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5001008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5001008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:41:09Z","timestamp":1777405269000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5001008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.5301\/ejo.5001008"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5001008","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}