{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:17:54Z","timestamp":1777580274291,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2017,11,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Gyrate atrophy of the choroid and retina (GACR) is a rare chorioretinal dystrophy characterized by a deficiency of the enzyme ornithine aminotransferase, inherited in an autosomal recessive pattern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>We report a case of a 17-year-old girl with GACR, for whom the level of serum ornithine had been reduced by an arginine-restricted diet. The patient was responsive to an association of topical nonsteroidal anti-inflammatory drugs (NSAIDs) and a carbonic anhydrase inhibitor (CAI) to reduce cystoid macular edema (CME).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The efficacy of topical NSAIDs and systemic CAI association indicates that the imbalance in the distribution of retinal pigment epithelium membrane-bound carbonic anhydrase could play a major role in CME pathogenesis in GACR. To our knowledge, this is the first case of therapy with CAI treatment for GACR-related CME.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5001010","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T10:01:56Z","timestamp":1500026516000},"page":"e179-e183","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Carbonic Anhydrase Inhibitor with Topical NSAID Therapy to Manage Cystoid Macular Edema in a Case of Gyrate Atrophy"],"prefix":"10.1177","volume":"27","author":[{"given":"Elena","family":"Piozzi","sequence":"first","affiliation":[{"name":"Pediatric Ophthalmology Unit, Niguarda Ca\u2019Granda Metropolitan Hospital, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Alessi","sequence":"additional","affiliation":[{"name":"Ophthalmology Section, Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, Palermo - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Santambrogio","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology Unit, Niguarda Ca\u2019Granda Metropolitan Hospital, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Cillino","sequence":"additional","affiliation":[{"name":"Ophthalmology Section, Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, Palermo - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Mazza","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology Unit, Niguarda Ca\u2019Granda Metropolitan Hospital, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aissa","family":"Iggui","sequence":"additional","affiliation":[{"name":"Ophthalmology Section, Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, Palermo - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Cillino","sequence":"additional","affiliation":[{"name":"Ophthalmology Section, Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, Palermo - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,8,11]]},"reference":[{"key":"bibr1-ejo.5001010","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.12.083"},{"key":"bibr2-ejo.5001010","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-199303320-00021"},{"key":"bibr3-ejo.5001010","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.09.017"},{"key":"bibr4-ejo.5001010","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2012.11.006"},{"key":"bibr5-ejo.5001010","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(81)35031-3"},{"key":"bibr6-ejo.5001010","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00587-X"},{"key":"bibr7-ejo.5001010","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.101386"},{"key":"bibr8-ejo.5001010","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.2.146"},{"key":"bibr9-ejo.5001010","author":"Wechsler D","year":"2013","journal-title":"Baltimore (MD), Williams & Witkins. 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