{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:54:35Z","timestamp":1784116475196,"version":"3.55.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Dry eye disease (DED) is a common condition causing substantial burden. A randomized, controlled, single-masked study was performed in 40 patients with mild to moderate DED to evaluate the efficacy and safety of a collyrium based on crosslinked hyaluronic acid (XLHA) with coenzyme Q10 (CoQ10).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Enrolled subjects were divided into 2 groups: group A, treated with XLHA + CoQ10; and group B, treated with hyaluronic acid (HA). Eyedrops were administered 4 times daily for 3 months. The Ocular Surface Disease Index (OSDI) questionnaire, tear break-up time (TBUT), corneal and conjunctival staining, and meibomian gland assessment (MGD) were evaluated; furthermore, corneal aesthesiometry, in vivo corneal confocal microscopy, visual acuity, intraocular pressure (IOP), and fundus examination were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At the end of treatment, OSDI score significantly decreased in groups A and B (p&lt;0.01 and p&lt;0.05, respectively); the decrease was significantly higher in group A. Corneal staining decreased in both groups, with lower scores in group A. The MGD was significantly ameliorated in group A patients. No differences were found for corneal aesthesiometry or TBUT. Epithelial cell reflectivity was significantly reduced only in group A. For keratocytes and stromal matrix parameters, there was a significant improvement in group A. No changes were found for visual acuity, IOP, or fundus examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The XLHA + CoQ10 treatment showed greater effectiveness in DED compared to HA alone, probably due to the longer permanency on ocular surface and the antioxidant activity of CoQ10. Therefore, XLHA + CoQ10 eyedrops could represent a new possibility in dry eye treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5001011","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T07:16:17Z","timestamp":1501830977000},"page":"25-31","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Efficacy of eyedrops containing cross-linked hyaluronic acid and coenzyme Q10 in treating patients with mild to moderate dry eye"],"prefix":"10.1177","volume":"28","author":[{"given":"Elisa I.","family":"Postorino","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Regional Referral Centre for the Ocular Surface Diseases, University of Messina, Messina - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rania","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Regional Referral Centre for the Ocular Surface Diseases, University of Messina, Messina - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Aragona","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Regional Referral Centre for the Ocular Surface Diseases, University of Messina, Messina - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mannucci","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Messina, Messina - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Alibrandi","sequence":"additional","affiliation":[{"name":"Department of Economics, Unit of Statistical and Mathematical Sciences, University of Messina, Messina - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioacchino","family":"Calapai","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Messina, Messina - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Puzzolo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Messina, Messina - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Aragona","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Regional Referral Centre for the Ocular Surface Diseases, University of Messina, Messina - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"bibr1-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2016.11.003"},{"key":"bibr2-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.11.060"},{"issue":"3","key":"bibr3-ejo.5001011","first-page":"S102","volume":"14","author":"Pflugfelder SC","year":"2008","journal-title":"Am J Manag Care"},{"key":"bibr4-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.10.014"},{"key":"bibr5-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1080\/09286580600801044"},{"key":"bibr6-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70082-4"},{"key":"bibr7-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S5555"},{"key":"bibr8-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00218-6"},{"key":"bibr9-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(01)80136-3"},{"key":"bibr10-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31819bc308"},{"key":"bibr11-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.07.048"},{"key":"bibr12-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666160614012634"},{"key":"bibr13-ejo.5001011","first-page":"1","volume":"5","author":"DEWS","year":"2007","journal-title":"Ocul Surf"},{"key":"bibr14-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.06.003"},{"key":"bibr15-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2003.09.003"},{"key":"bibr16-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2013.07.003"},{"key":"bibr17-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2010.519850"},{"key":"bibr18-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70081-2"},{"key":"bibr19-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.364"},{"key":"bibr20-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2012.02.001"},{"key":"bibr21-ejo.5001011","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S1496"},{"issue":"9","key":"bibr22-ejo.5001011","first-page":"1168","volume":"98","author":"Baudouin C","year":"2014","journal-title":"Diagnosing the severity of dry eye: a clear and practical algorithm. 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