{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:17:54Z","timestamp":1777580274288,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2017,11,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe a case of bilateral choroidal neovascularization (CNV) in multifocal choroiditis (MFC) associated with dabrafenib and trametinib chemotherapy for metastatic melanoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>We present a case of a 57-year-old man with MFC who underwent combination therapy with dabrafenib plus trametinib for metastatic melanoma. The patient presented to our ophthalmology department complaining of bilateral vision loss of 2 days\u2019 duration. He underwent multimodal imaging showing a MFC reactivation complicated by bilateral CNV. The patient underwent 3 ranibizumab injections in the right eye and 7 ranibizumab injections in the left eye. Anatomical and functional improvement has been observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This report emphasizes the importance of strict ophthalmologic follow-up in patients with metastatic melanoma treated with dabrafenib plus trametinib since rare severe ocular toxicities can occur, especially in patients with a history of uveitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5001013","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T07:16:17Z","timestamp":1501830977000},"page":"e184-e186","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Choroidal Neovascularization in Multifocal Choroiditis after Dabrafenib and Trametinib"],"prefix":"10.1177","volume":"27","author":[{"given":"Giorgia C.","family":"Albertini","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Vita-Salute University, IRCCS Ospedale San Raffaele, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Corbelli","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Vita-Salute University, IRCCS Ospedale San Raffaele, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Battaglia Parodi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Vita-Salute University, IRCCS Ospedale San Raffaele, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bandello","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Vita-Salute University, IRCCS Ospedale San Raffaele, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,8,11]]},"reference":[{"key":"bibr1-ejo.5001013","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412690"},{"key":"bibr2-ejo.5001013","doi-asserted-by":"publisher","DOI":"10.1177\/1758834014566428"},{"key":"bibr3-ejo.5001013","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60868-X"},{"key":"bibr4-ejo.5001013","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1210093"},{"key":"bibr5-ejo.5001013","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408868"},{"key":"bibr6-ejo.5001013","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2001148"},{"key":"bibr7-ejo.5001013","doi-asserted-by":"publisher","DOI":"10.1038\/nature09627"},{"key":"bibr8-ejo.5001013","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(86)33611-X"},{"key":"bibr9-ejo.5001013","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.5851"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5001013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/ejo.5001013","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ejo.5001013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:41:01Z","timestamp":1777405261000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ejo.5001013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11,8]]}},"alternative-id":["10.5301\/ejo.5001013"],"URL":"https:\/\/doi.org\/10.5301\/ejo.5001013","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}