{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:18:16Z","timestamp":1777580296588,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare the long-term results of big-bubble technique and microbubble techniques to complete stroma dissection after failure of achieving a big-bubble.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 35 eyes with keratoconus underwent lamellar keratoplasty with the big-bubble technique (15 eyes) or the microbubble technique (15 eyes). Conversion to penetrating keratoplasty was performed in 3 eyes of the big-bubble group and in 2 eyes of the microbubble group. Best-corrected visual acuity, corneal thickness, corneal astigmatism, and endothelial cell count were assessed preoperatively and at 12 and 24 months after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean preoperative visual acuity was 0.29 \u00b1 0.18 in the big-bubble group and 0.25 \u00b1 0.15 in the microbubble group. Postoperatively, all patients showed a regular interface between donor and recipient tissue. At 24 months, mean best-corrected visual acuity was 0.84 \u00b1 0.16 in the big-bubble group and 0.68 \u00b1 0.17 in the microbubble group (p = 0.013), and mean central corneal thickness was 530 \u00b1 39 \u00b5m in the big-bubble group and 545 \u00b1 30 \u00b5m in the microbubble group. Astigmatism was 2.41 \u00b1 1.29 D and 3.59 \u00b1 1.48 D (p = 0.036), respectively, while endothelial cell density was 1,671 \u00b1 371 in the big-bubble group and 1,567 \u00b1 275 in the microbubble group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The microbubble technique appears to be a valid alternative as it was safe and provided good functional results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.5001038","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T04:44:52Z","timestamp":1506919492000},"page":"243-245","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Microbubble technique in failed deep anterior lamellar keratoplasty: 2-year outcomes"],"prefix":"10.1177","volume":"28","author":[{"given":"Stefano","family":"Lippera","sequence":"first","affiliation":[{"name":"Eye Unit, \u201cE. Profili\u201d Hospital, Fabriano (Ancona) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Pallotta","sequence":"additional","affiliation":[{"name":"Eye Unit, \u201cE. Profili\u201d Hospital, Fabriano (Ancona) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Ferroni","sequence":"additional","affiliation":[{"name":"Eye Unit, \u201cE. Profili\u201d Hospital, Fabriano (Ancona) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrta","family":"Lippera","sequence":"additional","affiliation":[{"name":"Eye Unit, \u201cE. 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