{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:05:17Z","timestamp":1777676717377,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HIP International"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p>\n                    Wear debris is believed to cause periprosthetic osteolysis and loosening of total joint arthroplasties. We investigated the wear debris-mediated osteolysis in wild-type mice and macrophage-deficient Csf1\n                    <jats:sup>op<\/jats:sup>\n                    \/Csf1\n                    <jats:sup>op<\/jats:sup>\n                    (op\/op) mice using high density polyethylene (HDP) particles transplanted on the parietal bone surface. Four weeks after surgery, phagocytosis of the HDP particles by F4\/80-positive macrophages and tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts was observed in the normal mice, but not in the macrophage-deficient op\/op mice. These results suggest that macrophages are implicated in wear debris-dependent osteoclast formation. However, HDP particles were phagocytosed not only by macrophages but also by F4\/80-negative cells in both genotypes of mice. Electron microscopic observation identified these cells as fibroblasts. Cell culture studies demonstrated that fibroblasts cultured with HDP-particles showed upregulation of interleukin-6 (IL-6) expression compared with non-treated fibroblasts. When we examined the gene expression of osteoblasts that belong to the mesenchymal cell lineage as fibroblasts, we found that the expression of not only IL-6 but also interleukin-1 beta (IL-1\u03b2), tumor necrosis factor-alpha (TNF-\u03b1) and cyclooxygenase2 (Cox2) were up-regulated by HDP particle-stimulation. These findings suggest the possibility that fibroblasts and osteoblasts are involved in wear debris-mediated osteolysis within the tissue surrounding artificial joints through the production of bone resorbing factors IL-6, IL-1\u03b2, TNF-\u03b1, and Cox2.\n                  <\/jats:p>","DOI":"10.5301\/hip.2011.7977","type":"journal-article","created":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T03:21:32Z","timestamp":1304047292000},"page":"231-237","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Wear Debris Stimulates Bone-Resorbing Factor Expression in the Fibroblasts and Osteoblasts"],"prefix":"10.1177","volume":"21","author":[{"given":"Jiro","family":"Fujii","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Hiroshima Prefectural Rehabilitation Centre, Hiroshima - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumpei","family":"Niida","sequence":"additional","affiliation":[{"name":"Laboratory of Genomics and Proteomics, National Center for Geriatrics and Gerontology (NCGG), Obu, Aichi - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Hiroshima University School of Medicine, Hiroshima - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ohu University School of Density, Fukushima - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Ochi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Hiroshima University School of Medicine, Hiroshima - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,4,29]]},"reference":[{"key":"bibr1-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1080\/17453674.1998.11744778"},{"key":"bibr2-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199807000-00007"},{"key":"bibr3-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.04.035"},{"key":"bibr4-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.80B3.8158"},{"key":"bibr5-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.83B6.10905"},{"key":"bibr6-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2005.03.034"},{"key":"bibr7-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a108657"},{"key":"bibr8-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1038\/345442a0"},{"key":"bibr9-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1177\/35.2.3540104"},{"key":"bibr10-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.80B5.8513"},{"key":"bibr11-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199711000-00005"},{"key":"bibr12-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.2.338"},{"key":"bibr13-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199306000-00007"},{"key":"bibr14-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100140317"},{"key":"bibr15-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650100920"},{"key":"bibr16-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2004.10.006"},{"key":"bibr17-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.2.103"},{"key":"bibr18-hip.2011.7977","first-page":"713","volume":"32","author":"Mandelin J","year":"2005","journal-title":"J Rheumatol"},{"key":"bibr19-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1002\/art.22134"},{"key":"bibr20-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1007\/s11420-006-9003-6"},{"key":"bibr21-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1186\/ar2170"},{"key":"bibr22-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.931140"},{"key":"bibr23-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1007\/s00223001125"},{"key":"bibr24-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(00)00030-9"},{"key":"bibr25-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200102000-00007"},{"key":"bibr26-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-004-0808-1"},{"key":"bibr27-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025088418878"},{"key":"bibr28-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1007\/s007760170025"},{"key":"bibr29-hip.2011.7977","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200009)53:5<490::AID-JBM7>3.0.CO;2-7"}],"container-title":["HIP International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/hip.2011.7977","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/hip.2011.7977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:20:37Z","timestamp":1777450837000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/hip.2011.7977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.5301\/hip.2011.7977"],"URL":"https:\/\/doi.org\/10.5301\/hip.2011.7977","relation":{},"ISSN":["1120-7000","1724-6067"],"issn-type":[{"value":"1120-7000","type":"print"},{"value":"1724-6067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}