{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:55:41Z","timestamp":1790358941817,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"8_suppl","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HIP International"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Two-stage revision is the most widely accepted and performed intervention for chronically infected hip prosthesis and different interim spacers have been proposed. In recent years, antibiotic-loaded preformed spacers have become available on the market. The aim of this retrospective study was to assess the long-term results of two-stage revision with preformed spacers and uncemented hip prosthesis for the treatment of septic hip prosthesis.<\/jats:p>\n                  <jats:p>From 2000 to 2010, 183 consecutive patients underwent two-stage revision of septic hip prosthesis, with a same protocol, including preformed antibiotic-loaded cement spacer and a cementless modular hip revision prosthesis and four to six weeks antibiotic administration. Clinical and radiologic assessment at a minimum follow-up of two years was performed.<\/jats:p>\n                  <jats:p>At a minimum two years follow-up, 10 patients (5.4%) had had an infection recurrence, four (2.2%) an aseptic loosening and four more required partial revision of the modular components of the prosthesis, because of hip instability\/dislocation; 21 patients died or were lost to follow-up. Considering all the reasons for revision, survivorship at eleven years was 93.9%. Harris Hip Score improved from 29.1 \u00b1 14.6 pre-operatively to 41.1 \u00b1 15.9 after spacer implant and 81.7 \u00b1 17.6 after hip revision. The main complications after spacer implant included: spacer dislocation (16.4%), intra-operative femoral fractures (2.7%), and thromboembolism (2.1%). Complications after hip revision were: instability\/dislocation (4,3%), intra-operative femoral fractures (1.6%), and thromboembolism (3.3%).<\/jats:p>\n                  <jats:p>Two-stage revision of septic hip prosthesis with preformed antibiotic-loaded spacers and cementless hip prosthesis provides satisfactory long-term results, with reduced complications.<\/jats:p>","DOI":"10.5301\/hip.2012.9570","type":"journal-article","created":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T10:49:46Z","timestamp":1346928586000},"page":"46-53","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Preformed Antibiotic-Loaded Cement Spacers for Two-Stage Revision of                     Infected Total Hip Arthroplasty. Long-Term Results"],"prefix":"10.1177","volume":"22","author":[{"given":"Carlo L.","family":"Roman\u00f2","sequence":"first","affiliation":[{"name":"Centre for Reconstructive Surgery and\r                Osteo-articular Infections, IRCCS Galeazzi Orthopaedic Institute, Milan -\r                Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Roman\u00f2","sequence":"additional","affiliation":[{"name":"Centre for Reconstructive Surgery and\r                Osteo-articular Infections, IRCCS Galeazzi Orthopaedic Institute, Milan -\r                Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Albisetti","sequence":"additional","affiliation":[{"name":"Centre for Osteo-articular Septic\r                Complications Surgery, Gaetano Pini Orthopaedic Institute, Milan - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Meani","sequence":"additional","affiliation":[{"name":"Centre for Osteo-articular Septic\r                Complications Surgery, Gaetano Pini Orthopaedic Institute, Milan - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,6,9]]},"reference":[{"key":"bibr1-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.63B3.7021561"},{"key":"bibr2-HIP.2012.9570","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/00003086-198210000-00011","volume":"170","author":"Bittar ES","year":"1982","journal-title":"Clin Orthop Relat Res."},{"key":"bibr3-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197860080-00007"},{"key":"bibr4-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198971060-00005"},{"key":"bibr5-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199403000-00005"},{"key":"bibr6-HIP.2012.9570","first-page":"171","volume":"5","author":"Kendall RW","year":"1994","journal-title":"Semin Arthroplasty."},{"key":"bibr7-HIP.2012.9570","first-page":"305","volume":"44","author":"Duncan CP","year":"1995","journal-title":"Instr Course Lect."},{"key":"bibr8-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(99)90122-5"},{"key":"bibr9-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(97)90133-9"},{"key":"bibr10-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.3109\/17453679408993707"},{"key":"bibr11-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200704000-00026"},{"key":"bibr12-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1007\/s007760300004"},{"key":"bibr13-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1007\/s002640050244"},{"key":"bibr14-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.82B5.9668"},{"key":"bibr15-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2004.02.037"},{"key":"bibr16-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1054\/arth.2002.32698"},{"key":"bibr17-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(97)90133-9"},{"key":"bibr18-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000130757.53559.BF"},{"key":"bibr19-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200300004-00011"},{"key":"bibr20-HIP.2012.9570","first-page":"425","volume":"30","author":"Pearle AD","year":"2002","journal-title":"Am J Orthop."},{"key":"bibr21-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-003-0502-3"},{"key":"bibr22-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-003-0722-y"},{"key":"bibr23-HIP.2012.9570","first-page":"305","volume":"44","author":"Duncan CP","year":"1995","journal-title":"Instr Course Lect."},{"key":"bibr24-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(99)90234-6"},{"key":"bibr25-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1080\/000164701317269003"},{"key":"bibr26-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1243\/095441103762597665"},{"key":"bibr27-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1177\/112070000301300306"},{"key":"bibr28-HIP.2012.9570","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh032"},{"key":"bibr29-HIP.2012.9570","unstructured":"RomanoCL, MeaniE The use of pre-formed long stem antibiotic-loaded cement spacers\n                        for two-stage revisions of infected hip prosthesis. 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