{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:58:10Z","timestamp":1777676290672,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HIP International"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Peri-prosthetic osteolysis is a major cause for revision hip arthroplasty; various cytokines including those in the osteoclastogenesis pathway have been identified as potentially key in the osteolysis process. Adverse reactions to metal debris in metal-on-metal total hip replacements have led to an increase in revision procedures. This study examines the levels of osteoclastogenesis-related cytokines in serum and synovial fluid samples obtained from patients at the time of revision metal-on-metal total hip replacement and compares between patients with and without radiographic evidence of peri-prosthetic osteolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sandwich ELISA techniques were used to detect IL-6, IL-18, M-CSF, sRANKL and OPG in the samples. Results were analysed with linear regression, Fisher's tests and t-tests; p&lt;0.05 considered significant. Samples from 36 patients (18 with osteolysis, 18 without osteolysis) were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was wide variation in the detectable levels of cytokines. No significant differences were found between patients with and without osteolysis in mean synovial fluid levels of IL-6 (p = 0.863), IL-18 (p = 0.324), M-CSF (p = 0.508), sRANKL (p = 0.884), OPG (p = 0.776) or mean serum levels of OPG (p = 0.993) or sRANKL (p = 0.565) (insufficient detection of IL-6, IL-18 or M-CSF in serum samples). A correlation was found between synovial fluid levels of IL-6 and OPG in patients without osteolysis (r\n                      <jats:sup>2<\/jats:sup>\n                      = 0.618, p&lt;0.001) but not with osteolysis (r\n                      <jats:sup>2<\/jats:sup>\n                      = 0.0004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicate that the process of peri-prosthetic osteolysis is complex and multifactorial; there may also be an influence of metallosis. Further research is needed to increase understanding of peri-prosthetic osteolysis and influence clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/hipint.5000241","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T06:24:58Z","timestamp":1431930298000},"page":"355-360","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Osteoclastogenesis-Related Cytokines and Peri-Prosthetic Osteolysis in Revision Metal-On-Metal Total Hip Replacements"],"prefix":"10.1177","volume":"25","author":[{"given":"Sarah E.","family":"Eastwood","sequence":"first","affiliation":[{"name":"Department of Trauma and Orthopaedics, University Hospital Wales, Cardiff - UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alun","family":"John","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, University Hospital Wales, Cardiff - UK"},{"name":"Arthritis Research UK Biomechanics and Bioengineering Centre, Cardiff University, Cardiff - UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, University Hospital Wales, Cardiff - UK"},{"name":"Arthritis Research UK Biomechanics and Bioengineering Centre, Cardiff University, Cardiff - UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Hodgson","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, University Hospital Wales, Cardiff - UK"},{"name":"Arthritis Research UK Biomechanics and Bioengineering Centre, Cardiff University, Cardiff - UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Mason","sequence":"additional","affiliation":[{"name":"Arthritis Research UK Biomechanics and Bioengineering Centre, Cardiff University, Cardiff - UK"},{"name":"School of Biosciences, Cardiff University, Cardiff - UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Waddington","sequence":"additional","affiliation":[{"name":"Arthritis Research UK Biomechanics and Bioengineering Centre, Cardiff University, Cardiff - UK"},{"name":"Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, Cardiff - UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Wei","sequence":"additional","affiliation":[{"name":"Arthritis Research UK Biomechanics and Bioengineering Centre, Cardiff University, Cardiff - UK"},{"name":"Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, Cardiff - UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"bibr1-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820110202"},{"key":"bibr2-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-007-0364-3"},{"issue":"4","key":"bibr3-hipint.5000241","doi-asserted-by":"crossref","first-page":"455","DOI":"10.33549\/physiolres.930997","volume":"56","author":"Veigl D.","year":"2007","journal-title":"Physiol Res."},{"key":"bibr4-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63560-2"},{"key":"bibr5-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.018481"},{"key":"bibr6-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-012-9524-8"},{"key":"bibr7-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.83B6.10905"},{"key":"bibr8-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B1.28047"},{"key":"bibr9-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21135"},{"key":"bibr10-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.93B4.26429"},{"key":"bibr11-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.92B1.22770"},{"key":"bibr12-hipint.5000241","unstructured":"National Joint Registry for England, Wales and Northern Ireland, 10th Annual Report 2013. Available at www.njrcentre.org.uk. [http:\/\/njrcentre.org.uk\/njrcentre\/Portals\/0\/Documents\/England\/Reports\/10th_annual_report\/NJR%2010th-20Annual%20Report%202013.pdf] ISSN 2054-183X."},{"key":"bibr13-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.09.017"},{"key":"bibr14-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1080\/000164701753532835"},{"key":"bibr15-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00736.x"},{"issue":"1","key":"bibr16-hipint.5000241","first-page":"26","volume":"2","author":"Lis K.","year":"2014","journal-title":"Folia Medica Copernicana."},{"key":"bibr17-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.85B8.12799"},{"key":"bibr18-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.01038"},{"key":"bibr19-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.06.007"},{"key":"bibr20-hipint.5000241","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-12-74"},{"issue":"1","key":"bibr21-hipint.5000241","first-page":"34","volume":"10","author":"Sansone V.","year":"2013","journal-title":"Clin Cases Miner Bone Metab."}],"container-title":["HIP International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/hipint.5000241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/hipint.5000241","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/hipint.5000241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:18:19Z","timestamp":1777450699000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/hipint.5000241"}},"subtitle":["The Work Was Presented at the 11\n                    <sup>th<\/sup>\n                    European Hip Society Congress; October 11, 2014, Stockholm, Sweden. Awarded Prize for Best Oral Presentation"],"short-title":[],"issued":{"date-parts":[[2015,4,24]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.5301\/hipint.5000241"],"URL":"https:\/\/doi.org\/10.5301\/hipint.5000241","relation":{},"ISSN":["1120-7000","1724-6067"],"issn-type":[{"value":"1120-7000","type":"print"},{"value":"1724-6067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,24]]}}}