{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:01:11Z","timestamp":1777676471563,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HIP International"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Modular necks in total hip replacement (THR) can be a source of metal ion release.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured the level of cobalt (Co) and chromium (Cr) ions in the serum of 23 healthy volunteers with a well-functioning ceramic-on-ceramic THR of a particular design, containing a cobalt-chrome (Co-Cr) stem and a Co-Cr modular neck.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Average Co in serum was 1,71 \u03bcg\/l; median Co was 1.50 \u03bcg\/l. No patient had Co levels higher than 3.70 \u03bcg\/l. Average Cr level was 0.49 \u03bcg\/l; in all but one patient Cr was below the detection limit (\u22640.50 \u03bcg\/l). Co was higher for varus necks compared to all other subtypes: 2.14 \u03bcg\/l vs 1.58 \u03bcg\/l (p\u22640.05). The same system with Titanium modular necks shows lower Co serum levels: 1.26 \u03bcg\/l (p\u22640.01). In conclusion, the hybrid THR Profemur Xm\u00ae \u2013 Procotyle L\u00ae with a Co-Cr modular neck on a Co-Cr stem design shows very low Cr ion serum levels in a randomly selected group of well-functioning hip patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Co ion serum levels are low, but significantly higher for 8\u00b0 varus necks, and Co levels are significantly higher than values of this system with a Titanium modular neck.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/hipint.5000430","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T05:24:16Z","timestamp":1477632256000},"page":"21-25","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Metal Ion Levels in Ceramic-on-Ceramic THR with Cobalt-Chrome Modular Necks: Analysis of Cobalt and Chromium Serum Levels in 23 Healthy Hip Patients"],"prefix":"10.1177","volume":"27","author":[{"given":"Jan F.A.","family":"Somers","sequence":"first","affiliation":[{"name":"Department of Orthopaedic and General Surgery, Jan Yperman Hospital, Ypres - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieven","family":"Dedrye","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic and General Surgery, Jan Yperman Hospital, Ypres - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie","family":"Goeminne","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Catholic University of Leuven, Leuven - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,10,24]]},"reference":[{"issue":"1","key":"bibr1-hipint.5000430","first-page":"81","volume":"75","author":"Toni A.","year":"1990","journal-title":"Chir Organi Mov."},{"key":"bibr2-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2013.01.018"},{"key":"bibr3-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-196850030-00013"},{"key":"bibr4-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31794"},{"key":"bibr5-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.5301\/hipint.5000257"},{"key":"bibr6-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.00533"},{"key":"bibr7-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.95B8.31525"},{"key":"bibr8-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B7.29122"},{"key":"bibr9-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199705)35:2<207::AID-JBM9>3.0.CO;2-R"},{"key":"bibr10-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2014.04.039"},{"key":"bibr11-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.12.001"},{"key":"bibr12-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2015.04.040"},{"key":"bibr13-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-015-2894-4"},{"key":"bibr14-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2014.01.040"},{"key":"bibr15-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01042"},{"key":"bibr16-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.M.00979"},{"key":"bibr17-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01625"},{"key":"bibr18-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2010.03.011"},{"key":"bibr19-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2011.05.024"},{"key":"bibr20-hipint.5000430","first-page":"591509","volume":"2015","author":"Hernandez A.","year":"2015","journal-title":"Case Rep Orthop."},{"key":"bibr21-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2526-x"},{"key":"bibr22-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-3-6"},{"key":"bibr23-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.97B9.34824"},{"key":"bibr24-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.96B9.33476"},{"key":"bibr25-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2011.04.007"},{"key":"bibr26-hipint.5000430","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2011.08.002"}],"container-title":["HIP International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/hipint.5000430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/hipint.5000430","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/hipint.5000430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:19:03Z","timestamp":1777450743000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/hipint.5000430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,24]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.5301\/hipint.5000430"],"URL":"https:\/\/doi.org\/10.5301\/hipint.5000430","relation":{},"ISSN":["1120-7000","1724-6067"],"issn-type":[{"value":"1120-7000","type":"print"},{"value":"1724-6067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,24]]}}}