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Bone is an optimal substratum for S. aureus, since this bacterium expresses various adhesins by which can adhere to bone proteins and to the biomaterial surfaces coated with the proteins of the host extracellular matrix. S. aureus is able not only to colonize bone tissues, but also to invade and disrupt them by entering bone cells and inducing cell death and osteolysis. Here we illustrate the pathogenetic mechanisms that can explain how the osteomyelitis sets in and develops around an implant.<\/jats:p>","DOI":"10.5301\/ijao.5000052","type":"journal-article","created":{"date-parts":[[2011,11,20]],"date-time":"2011-11-20T10:40:28Z","timestamp":1321785628000},"page":"781-788","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":63,"title":["Emerging Pathogenetic Mechanisms of the Implant-Related Osteomyelitis by\n                    <i>Staphylococcus Aureus<\/i>"],"prefix":"10.1177","volume":"34","author":[{"given":"Lucio","family":"Montanaro","sequence":"first","affiliation":[{"name":"Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna - Italy"},{"name":"Department of Experimental Pathology, University of Bologna, Bologna - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Testoni","sequence":"additional","affiliation":[{"name":"Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Poggi","sequence":"additional","affiliation":[{"name":"Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna - Italy"},{"name":"Medicine and Surgery School, University of Modena and Reggio Emilia, Modena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Visai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Pavia, Pavia - Italy"},{"name":"Center for Tissue Engineering (C.I.T.), University of Pavia, and Salvatore Maugeri Foundation IRCCS, Pavia - Italy"},{"name":"International Center for Studies and Research in Biomedicine (I.C.B.) - Luxembourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Speziale","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Pavia, Pavia - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Renata","family":"Arciola","sequence":"additional","affiliation":[{"name":"Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna - Italy"},{"name":"Department of Experimental Pathology, University of Bologna, Bologna - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,11,17]]},"reference":[{"key":"bibr1-ijao.5000052","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.89B5.19170"},{"key":"bibr2-ijao.5000052","doi-asserted-by":"publisher","DOI":"10.1007\/BF00692640"},{"key":"bibr3-ijao.5000052","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704033361406"},{"key":"bibr4-ijao.5000052","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16727-5. 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