{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:20:25Z","timestamp":1792790425180,"version":"4.5.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The present study evaluated in vitro and in vivo the effects of quercetin (QC), a major ingredient in various flavonoids, on peripheral nerve regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the in vitro study, we found that QC at concentrations of 0.1, 1, and 10 \u03bcg\/mL could significantly promote the survival and outgrowth of cultured Schwann cells as compared with the controls treated with culture medium only. In the in vivo study, we evaluated peripheral nerve regeneration across a 15-mm gap in the sciatic nerve of the rat, using a silicone rubber nerve chamber filled with the QC solution. In the control group, the chambers were filled with normal saline only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the end of 8 weeks, morphometric data revealed that all 3 QC groups significantly increased the count and density of myelinated axons as compared with the controls. Electro-physiological measurements showed that the QC-treated group at 1 \u03bcg\/mL had a significantly larger area of evoked muscle action potential (MAP) compared with the controls. In addition, the amplitude of the MAP in the QC-treated groups at 0.1 and 1 \u03bcg\/mL was significantly larger than that in the controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>All of these results indicate that QC treatment has nerve growth\u2013promoting effects which may lead to a promising herbal medicine for the recovery of regenerating peripheral nerves.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ijao.5000064","type":"journal-article","created":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T16:18:34Z","timestamp":1363018714000},"page":"1095-1105","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Growth-Promoting Effects of Quercetin on Peripheral Nerves in Rats"],"prefix":"10.1177","volume":"34","author":[{"given":"Walter","family":"Wang","sequence":"first","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung - Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung - Taiwan"},{"name":"Department of Health and Nutrition Biotechnology, Asia University, Taichung - Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuu-Jen","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung - Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chuan","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung - Taiwan"},{"name":"Chinese Medicine Department, E-Da Hospital, Kaohsiung - Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hsu","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung - Taiwan"},{"name":"Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung - Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung - Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,12,15]]},"reference":[{"key":"bibr1-ijao.5000064","doi-asserted-by":"publisher","DOI":"10.1016\/j.cxom.2010.11.001"},{"key":"bibr2-ijao.5000064","doi-asserted-by":"publisher","DOI":"10.1227\/01. 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