{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:08:09Z","timestamp":1777784889350,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To compare bicarbonate kinetics and acid base status in HD and HDF for the same patient; and to investigate the effect of patient physiologic parameters on these kinetics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In order to monitor HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      kinetics during dialysis, acid-base parameters, pH, blood gases partial pressures, and HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      concentrations were recorded during 3 regular dialysis (HD) and 3 on-line post-dilution HDF sessions performed on 12 patients, using same dialysis fluid with a 38 mmol\/l HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      concentration. HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      mass transfers through the hemodialyzers membranes and into the patients were continuously calculated during the sessions from HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      concentrations, together with HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      dialysance. The \u201capparent\u201d HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      gain was calculated by integrating over time the instantaneous mass transfer from dialyzer and re-infusion fluid to the patient. A second method consisted in calculating the patient apparent bicarbonate space (ABS) and HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      mass (ABS times plasma concentration) at beginning and end of session.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      No significant differences were observed between acid base parameters at the end of HD and HDF sessions. In contrast to urea clearances, HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      dialysances decayed with time during sessions from 110 to 140 ml\/min to about 40 ml\/min after one hour. The net HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      gain was taken as the difference between final and initial HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      masses. This net gain was in average 63% of apparent gain in HD and 74% in HDF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Uremic acidosis was well corrected without risk of alkalosis. An unexpected result was the continuous decay of bicarbonate dialysance both in HD and HDF during runs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ijao.5000082","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T11:20:03Z","timestamp":1334143203000},"page":"288-300","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["A Comparison of Bicarbonate Kinetics and Acid-base Status in High Flux Hemodialysis and On-Line Post-Dilution Hemodiafiltration"],"prefix":"10.1177","volume":"35","author":[{"given":"H\u00e9l\u00e8ne","family":"Morel","sequence":"first","affiliation":[{"name":"Technological University of Compi\u00e8gne, Department of Biological Engineering, Compi\u00e8gne - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel Y.","family":"Jaffrin","sequence":"additional","affiliation":[{"name":"Technological University of Compi\u00e8gne, Department of Biological Engineering, Compi\u00e8gne - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9ment","family":"Lux","sequence":"additional","affiliation":[{"name":"Technological University of Compi\u00e8gne, Department of Biological Engineering, Compi\u00e8gne - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Renou","sequence":"additional","affiliation":[{"name":"Departments of Nephrology, Hopital Sud, Amiens - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Fessier","sequence":"additional","affiliation":[{"name":"Pharmacology, Hopital Sud, Amiens - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abir","family":"Petit","sequence":"additional","affiliation":[{"name":"Pharmacology, Hopital Sud, Amiens - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Morini\u00e8re","sequence":"additional","affiliation":[{"name":"Departments of Nephrology, Hopital Sud, Amiens - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Legallais","sequence":"additional","affiliation":[{"name":"Technological University of Compi\u00e8gne, Department of Biological Engineering, Compi\u00e8gne - France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,11,4]]},"reference":[{"key":"bibr1-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.suppl_1.45"},{"key":"bibr2-ijao.5000082","volume-title":"Composition and management of hemodialysis fluids.","author":"Grassmann A.","year":"2000"},{"key":"bibr3-ijao.5000082","first-page":"145","volume":"16","author":"Thews O.","year":"1990","journal-title":"Med Prog Technol."},{"key":"bibr4-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.1177\/039139889201500801"},{"key":"bibr5-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.3109\/00365516009062421"},{"key":"bibr6-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.1177\/039139888801100111"},{"key":"bibr7-ijao.5000082","first-page":"38","volume-title":"Replacement of Renal Function by Dialysis.","author":"Sargent J.A.","year":"1978"},{"key":"bibr8-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.1177\/039139889902200207"},{"key":"bibr9-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.1177\/039139880202500204"},{"key":"bibr10-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.1177\/039139889802100601"},{"key":"bibr11-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2005.00126.x"},{"key":"bibr12-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.1177\/039139880903200802"},{"key":"bibr13-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-7388(99)00297-5"},{"key":"bibr14-ijao.5000082","unstructured":"PelletM.V. Physiologie humaine, I. Milieu int\u00e9rieur compartiments liquidiens. Paris: SIMEP; 1977: 92."},{"key":"bibr15-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.1080\/00365518809168181"},{"key":"bibr16-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1996.tb04583.x"},{"key":"bibr17-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.258"},{"key":"bibr18-ijao.5000082","volume-title":"Acid-base balances in on-line hemodiafiltration: modelisation; in vitro and clinical analyses of bicarbonate transfers.","author":"Morel H.","year":"2009"},{"key":"bibr19-ijao.5000082","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.162."}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ijao.5000082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ijao.5000082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:42:14Z","timestamp":1777491734000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ijao.5000082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.5301\/ijao.5000082"],"URL":"https:\/\/doi.org\/10.5301\/ijao.5000082","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}