{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:08:43Z","timestamp":1777784923914,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Aortic valve regurgitation or the presence of a mechanical aortic valve prosthesis is a relative contraindication for implantation of left ventricular assist devices (LVAD). However, concomitant aortic valve replacement by a biological prosthesis is one of the options in this situation. We analyzed our recent experience with left ventricular assist device implantation and concomitant aortic valve replacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Between January 1, 2008 and January 15, 2012, 318 adult patients (&gt;18 years old) were supported with a long-term implantable LVAD in our institution. In 19, simultaneous aortic valve replacement (6 redo and 13 primary procedures) was performed. Patients were divided into 2 groups according to INTERMACS (IM) level: Group 1 (n = 7) consisted of patients with IM level 1\u20132 and Group 2 (n = 12) of IM level 3\u20134 patients. As a control cohort we analyzed all LVAD recipients during the study period (n = 299, study group excluded). The control cohort was similarly divided into two groups according to the IM level: Group 3 (n = 162) consisted of patients with IM level 1\u20132 and Group 4 (n = 137) of those with IM level 3\u20135. Perioperative data and outcomes in all groups were retrospectively analyzed and compared (Group 1 compared to Group 3; and Group 2 to Group 4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In study Groups 1 and 2 all patients were male; in Groups 3 and 4, 80% and 88% respectively were male. Median age distribution in Groups was 55, 61, 54, and 57 years respectively. Patients from Group 2 were significantly older than those from Group 4 (p = 0.039). Body mass index was significantly lower in Group 1 than in Group 3 (p = 0.033). Cardio-pulmonary bypass time was significantly longer in Groups 1 and 2 compared with Groups 3 and 4 respectively (p\u22640.001). Patients from Group 1 had a trend more often to develop right ventricular failure requiring a right ventricular assist device (RVAD) than those in Group 3 (p = 0.09). Intensive care unit stay duration of mechanical ventilation and in-hospital mortality in Group 1 were significantly higher than in Group 3 (p = 0.025, p = 0.005, p = 0.038). Patients from Group 2 had similar outcomes compared to those from Group 4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In stable patients, simultaneous aortic valve replacement and LVAD implantation are not associated with an impaired outcome. In patients with cardiogenic shock an additional aortic valve replacement may impair outcome; therefore alternative techniques should be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ijao.5000102","type":"journal-article","created":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T06:27:55Z","timestamp":1338532075000},"page":"489-494","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Simultaneous Aortic Valve Replacement in left Ventricular Assist Device Recipients: Single-Center Experience"],"prefix":"10.1177","volume":"35","author":[{"given":"Nikolay","family":"Dranishnikov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Stepanenko","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenij V.","family":"Potapov","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Dandel","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henryk","family":"Siniawski","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Mladenow","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"H\u00fcbler","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onnen","family":"Grauhan","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuguo","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Krabatsch","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Hetzer","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Kukucka","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"issue":"5","key":"bibr1-ijao.5000102","first-page":"II309","volume":"88","author":"Holman W.L.","year":"1993","journal-title":"Circulation."},{"key":"bibr2-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.01.011"},{"key":"bibr3-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2009.221036"},{"key":"bibr4-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2006.143784"},{"key":"bibr5-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.10.004"},{"key":"bibr6-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.02.015"},{"key":"bibr7-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.02.012"},{"key":"bibr8-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.11.020"},{"key":"bibr9-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1111\/j.0886-0440.2004.04101.x"},{"key":"bibr10-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02479-1"},{"key":"bibr11-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.08.025"},{"key":"bibr12-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)01301-1"},{"key":"bibr13-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.11.003"},{"key":"bibr14-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.11.007"},{"key":"bibr15-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909938"},{"key":"bibr16-ijao.5000102","author":"Unbehaun A.","year":"2011","journal-title":"J Thorac Cardiovasc Surg."},{"key":"bibr17-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.09.049"},{"key":"bibr18-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.11.019"},{"key":"bibr19-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.06.023"},{"key":"bibr20-ijao.5000102","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)01180-4"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ijao.5000102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ijao.5000102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:42:20Z","timestamp":1777491740000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ijao.5000102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,6]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.5301\/ijao.5000102"],"URL":"https:\/\/doi.org\/10.5301\/ijao.5000102","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,6]]}}}