{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:08:54Z","timestamp":1777784934833,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The Sorin Pericarbon Freedom (SPF) is a stentless valve made of pericardium clinically available in 1990. We report the clinical and hemodynamic performance of the SPF at 10 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>From April 2000 to December 2005, 85 patients with a mean age of 75 \u00b1 6 years (range 57\u201386), underwent aortic valve replacement (AVR) with an SPF. Mean left ventricular ejection fraction was 58 \u00b1 10% (range 29\u201386%) and mean peak transvalvular gradient (PG) 86 \u00b1 24 mm Hg. Clinical evaluation was performed at 3, 6, 12 months, and yearly thereafter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 2 operative deaths (2.4%). Follow-up ranged from 2 to 135 months (mean 78 \u00b1 32 months) and was 99% complete. There were 35 late deaths, 7 of which were valve-related, with an actuarial survival of 45 \u00b1 8% at 10 years. Structural SPF deterioration occurred in 2 patients, with an actuarial freedom of 96 \u00b1 3%. A total of 4 patients were re-operated, 2 because of structural deterioration, 1 because of endocarditis, and 1 because of sinotubular junction dilatation; freedom from reoperation was 93 \u00b1 4% at 10 years. At last clinical control, 41 patients (89%) were in NYHA class I or II. Mean SPF effective orifice area varied from 1.55 \u00b1 0.66 cm\n                      <jats:sup>2<\/jats:sup>\n                      for size 21 mm to 2.33 \u00b1 0.86 cm\n                      <jats:sup>2<\/jats:sup>\n                      for size 27 mm; PG varied from 19 \u00b1 10 mm Hg for size 21 mm to 11 \u00b1 6 mm Hg for size 27 mm. Left ventricular mass index decreased from 213 \u00b1 51 gm\/m\n                      <jats:sup>2<\/jats:sup>\n                      to 157 \u00b1 436 gm\/m\n                      <jats:sup>2<\/jats:sup>\n                      (p&lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The SPF has demonstrated overall good results in terms of valve durability and freedom from valve-related complications up to 10 years, with excellent hemodynamic performance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ijao.5000103","type":"journal-article","created":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T06:23:34Z","timestamp":1338531814000},"page":"481-488","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Sorin Freedom Stentless Pericardial Valve: Clinical and Echocardiographic Performance at 10 years"],"prefix":"10.1177","volume":"35","author":[{"given":"Aldo D.","family":"Milano","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery, University of Verona Medical School, Verona - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Dodonov","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, University of Verona Medical School, Verona - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Celiento","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Cardiac Thoracic and Vascular Department, University Hospital, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Pizzuti","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, University of Verona Medical School, Verona - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Golia","sequence":"additional","affiliation":[{"name":"Cardiology, University of Verona Medical School, Verona - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Faggian","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, University of Verona Medical School, Verona - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uberto","family":"Bortolotti","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Cardiac Thoracic and Vascular Department, University Hospital, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Mazzucco","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, University of Verona Medical School, Verona - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"bibr1-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)35640-5"},{"key":"bibr2-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70001-6"},{"issue":"19","key":"bibr3-ijao.5000103","first-page":"II6","volume":"100","author":"Walther T.","year":"1999","journal-title":"Circulation."},{"key":"bibr4-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.05.055"},{"key":"bibr5-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.04.068"},{"issue":"1","key":"bibr6-ijao.5000103","first-page":"S102","volume":"4","author":"Stacchino C.","year":"1995","journal-title":"J Heart Valve Dis."},{"issue":"4","key":"bibr7-ijao.5000103","first-page":"62","volume":"11","author":"Westaby S.","year":"1999","journal-title":"Semin Thorac Cardiovasc Surg."},{"key":"bibr8-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-837638"},{"key":"bibr9-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1177\/021849230601400210"},{"key":"bibr10-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.04.020"},{"issue":"1","key":"bibr11-ijao.5000103","first-page":"91","volume":"16","author":"Beholz S.","year":"2007","journal-title":"J Heart Valve Dis."},{"key":"bibr12-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.12.002"},{"key":"bibr13-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.07.045"},{"issue":"1","key":"bibr14-ijao.5000103","first-page":"72","volume":"14","author":"Nagy Z.L.","year":"2005","journal-title":"J Heart Valve Dis."},{"issue":"5","key":"bibr15-ijao.5000103","first-page":"623","volume":"14","author":"Grubitzsch H.","year":"2005","journal-title":"J Heart Valve Dis."},{"issue":"1","key":"bibr16-ijao.5000103","first-page":"42","volume":"16","author":"Nyawo B.","year":"2007","journal-title":"J Heart Valve Dis."},{"key":"bibr17-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.05.022"},{"key":"bibr18-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.05.068"},{"key":"bibr19-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.01.046"},{"key":"bibr20-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.03.042"},{"key":"bibr21-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90638-6"},{"key":"bibr22-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)36282-8"},{"key":"bibr23-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)91099-0"},{"issue":"5","key":"bibr24-ijao.5000103","first-page":"531","volume":"20","author":"D'Onofrio A.","year":"2011","journal-title":"J Heart Valve Dis."},{"issue":"1","key":"bibr25-ijao.5000103","first-page":"115","volume":"19","author":"Beholz S.","year":"2010","journal-title":"J Heart Valve Dis."},{"key":"bibr26-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2007.169326"},{"key":"bibr27-ijao.5000103","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2008.188524"},{"issue":"3","key":"bibr28-ijao.5000103","first-page":"313","volume":"20","author":"Reents W.","year":"2011","journal-title":"J Heart Valve Dis."}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ijao.5000103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/ijao.5000103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:42:21Z","timestamp":1777491741000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/ijao.5000103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,6]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.5301\/ijao.5000103"],"URL":"https:\/\/doi.org\/10.5301\/ijao.5000103","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,6]]}}}