{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T04:58:03Z","timestamp":1777784283954,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T00:00:00Z","timestamp":1439164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a growing evidence for autoimmunity in acute central nervous system (CNS) disorders and treatment with therapeutic plasma exchange (TPE) may be considered. The aim was to share our experience on the clinical application of TPE in these disorders and to present a reproducible protocol which can be used even in small children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We present a series of 8 children aged 2-12 years with transverse myelitis, Bickerstaff's brainstem encephalitis, neuromyelitis optica, and acute paraneoplastic or unspecified encephalitis in whom TPE was used as a second-line or rescue treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 104 TPE sessions were performed where 80\u2013110 ml\/kg of plasma was exchanged using 4% albumin solution and fresh frozen plasma. Six episodes of TPE-related adverse events were documented. Fibrinogen concentrations decreased after the first TPE, whereas platelets decreased gradually. One patient died in the course of the acute illness. Three children achieved a complete resolution of symptoms, 2 children have mild sequelae; whereas 2 children remain paraplegic after a follow-up of 3 to 17 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We report 8 children with presumably autoimmune-mediated, acute CNS disorders treated with TPE as a rescue therapy. Although the effect of TPE can only be inferred, 5 children had a good clinical outcome. TPE is feasible even in small children with acute autoimmune CNS disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ijao.5000435","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T06:44:35Z","timestamp":1444373075000},"page":"494-500","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Therapeutic Plasma Exchange in Children with Acute Autoimmune Central Nervous System Disorders"],"prefix":"10.1177","volume":"38","author":[{"given":"Agnieszka","family":"Prytu\u0142a","sequence":"first","affiliation":[{"name":"Pediatric Nephrology and Rheumatology Department, Ghent University Hospital, Ghent - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan Vande","family":"Walle","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology and Rheumatology Department, Ghent University Hospital, Ghent - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Verhelst","sequence":"additional","affiliation":[{"name":"Pediatric Neurology and Metabolic Disease Department, Ghent University Hospital, Ghent - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunny","family":"Eloot","sequence":"additional","affiliation":[{"name":"Hemodialysis Unit, Ghent University Hospital, Ghent - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefaan","family":"Claus","sequence":"additional","affiliation":[{"name":"Hemodialysis Unit, Ghent University Hospital, Ghent - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annick","family":"De Jaeger","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Ghent University Hospital, Ghent - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Dehoorne","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology and Rheumatology Department, Ghent University Hospital, Ghent - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Raes","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology and Rheumatology Department, Ghent University Hospital, Ghent - 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