{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:39:45Z","timestamp":1777790385069,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Previous studies have revealed a conflicting relationship of xeroderma pigmentosum group G (XPG) gene polymorphism with gastric cancer (GC) risk. To our knowledge, this is the first meta-analysis to investigate the association between rs751402 mutation located on the XPG promoter region and GC risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We undertook a meta-analysis by identifying relevant articles from the PubMed, Web of Science and China National Knowledge Infrastructure (CNKI) databases on February 28, 2017. By pooling 9 eligible studies, 3,539 GC cases and 3,948 controls were included. The pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated using the fixed-effects or random-effects model depending on the existence of heterogeneity across studies. The population attributable risk (PAR%) was estimated to better understand the public health risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All included studies had been conducted in China. Significant associations were found between the XPG rs751402 polymorphism and the risk of GC (TT vs. CC: OR = 1.43, 95% CI, 1.11-1.84; CT vs. CC: OR = 1.15, 95% CI, 1.04-1.26; dominant model: OR = 1.17, 95% CI, 1.07-1.29; recessive model: OR = 1.30, 95% CI, 1.05-1.62; T vs. C: OR = 1.18, 95% CI, 1.06-1.32). The estimated PAR% was about 4.9%-8.8%. Funnel plots did not reveal any potential publication bias. The sensitivity analyses showed that the results were relatively robust.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This meta-analysis indicates that the XPG rs751402 polymorphism may be a risk factor for GC in the Chinese population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ijbm.5000313","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T04:47:38Z","timestamp":1510894058000},"page":"174-179","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of XPG gene rs751402 polymorphism with gastric cancer risk: a meta-analysis in the Chinese population"],"prefix":"10.1177","volume":"33","author":[{"given":"Jun","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Hefei Fourth People\u2019s Hospital, Hefei - PR China"},{"name":"Anhui Mental Health Center, Hefei - PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Yun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hefei Fourth People\u2019s Hospital, Hefei - PR China"},{"name":"Anhui Mental Health Center, Hefei - PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Prevention and Treatment Center for Occupational Diseases, Hefei - PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Rong","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hefei Fourth People\u2019s Hospital, Hefei - PR China"},{"name":"Anhui Mental Health Center, Hefei - PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"bibr1-ijbm.5000313","unstructured":"World Health Organization (WHO). GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_population.aspx. Accessed November 4, 2017."},{"key":"bibr2-ijbm.5000313","unstructured":"World Health Organization. Cancer. http:\/\/www.who.int\/mediacentre\/factsheets\/fs297\/en\/. Accessed March 6, 2017."},{"key":"bibr3-ijbm.5000313","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/437348"},{"key":"bibr4-ijbm.5000313","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30354-3"},{"key":"bibr5-ijbm.5000313","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldn007"},{"key":"bibr6-ijbm.5000313","unstructured":"World Health Organization. Genes and human disease. http:\/\/www.who.int\/genomics\/public\/geneticdiseases\/en\/index3.html. 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