{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:19:12Z","timestamp":1777789152200,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study was to develop a minimally invasive hydrogel system that can release strontium ions, an element that has been shown to increase osteoblast proliferation and prohibit bone resorption, in a controlled manner.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      SrCO\n                      <jats:sub>3<\/jats:sub>\n                      was selected as the salt of choice due to potential acid neutralization reaction between SrCO\n                      <jats:sub>3<\/jats:sub>\n                      and degradation by-products of methoxy(polyethylene glycol)- co-poly(lactic- co-glycolic acid) (mPEG-PLGA): namely, lactic acid and glycolic acid. SrCO\n                      <jats:sub>3<\/jats:sub>\n                      was incorporated into mPEG-PLGA hydrogel, and the system was assessed for gelation properties, drug release and biocompatibility.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SrCO\n                      <jats:sub>3<\/jats:sub>\n                      incorporation at hydrogel to SrCO\n                      <jats:sub>3<\/jats:sub>\n                      ratios of 5:1, 3:1 and 1:1 (wt%) did not compromise the thermosensitivity of mPEG-PLGA hydrogels. Furthermore, incorporation of SrCO\n                      <jats:sub>3<\/jats:sub>\n                      at 1:1 ratio prevented copolymer self-catalysis and decreased hydrogel weight loss from 85% to 61% in vitro after 30 days. During the 30-day time frame, zero-order strontium release was observed and was correlated to hydrogel degradation and acidity. The addition of SrCO\n                      <jats:sub>3<\/jats:sub>\n                      also improved in vivo hydrogel biocompatibility, due to moderation of acidic microenvironment and amelioration of inflammatory response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results showed that the described system is suitable for the extended release of strontium and exhibits potential for localized treatment for osteoporosis or as a bone void filler.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/jabfm.5000313","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T05:39:03Z","timestamp":1475818743000},"page":"162-169","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Controlled Release of Strontium through Neutralization Reaction within a Methoxy(Polyethylene Glycol)-Polyesterc hydrogel"],"prefix":"10.1177","volume":"15","author":[{"given":"Sydney","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, National Tsing Hua University, Hsinchu - Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Teng","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, National Tsing Hua University, Hsinchu - Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding-Wei","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, National Tsing Hua University, Hsinchu - Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-Ming","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, National Tsing Hua University, Hsinchu - 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