{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:30:01Z","timestamp":1777789801150,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>Soluble mesothelin-related peptide (SMRP) is a biomarker that has been proposed for differential diagnosis from pleural metastatic cancer, as well as prognosis and treatment monitoring of malignant pleural mesothelioma (MM). The aim of this study was to evaluate the role of SMRP in clinic management of MM. We assayed the SMRP concentrations in 354 subjects: 109 healthy volunteers with no history of exposure to asbestos, 26 patients with previous occupational asbestos exposure but who were free from pleural or parenchymal disease, 48 patients with asbestosis, 110 patients with pleural plaques, 25 patients with lung cancer, and 36 patients with MM. We also tested SMRP titers in 2 patients with MM at 5 different times of the disease, to evaluate the trend of the biomarker in the course of therapy. Our data confirm previous experiences with the use of SMRP as a diagnostic marker of MM. Low SMRP levels at diagnosis seem to have a positive prognostic significance.<\/jats:p>","DOI":"10.5301\/jbm.2011.8614","type":"journal-article","created":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T07:52:37Z","timestamp":1315209157000},"page":"160-165","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Biomarkers in Malignant Mesothelioma: Diagnostic and Prognostic Role of Soluble Mesothelin-Related Peptide"],"prefix":"10.1177","volume":"26","author":[{"given":"Nicola","family":"Dipalma","sequence":"first","affiliation":[{"name":"Department of Occupational Medicine, \u201cPoliclinico\u201d University Hospital, Bari - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Luisi","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, \u201cPoliclinico\u201d University Hospital, Bari - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Di Serio","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, \u201cPoliclinico\u201d University Hospital, Bari - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonietta","family":"Fontana","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, \u201cPoliclinico\u201d University Hospital, Bari - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piera","family":"Maggiolini","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, \u201cPoliclinico\u201d University Hospital, Bari - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brunella","family":"Licchelli","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, \u201cPoliclinico\u201d University Hospital, Bari - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Mera","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, \u201cPoliclinico\u201d University Hospital, Bari - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Bisceglia","sequence":"additional","affiliation":[{"name":"Environmental Protection Agency (ARPA Puglia), Bari - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Galise","sequence":"additional","affiliation":[{"name":"Environmental Protection Agency (ARPA Puglia), Bari - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Loizzi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, \u201cPoliclinico\u201d University Hospital, Bari - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Annunziata","family":"Pizzigallo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, \u201cPoliclinico\u201d University Hospital, Bari - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Molinini","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, \u201cPoliclinico\u201d University Hospital, Bari - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Vimercati","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Public Medicine, Section of Occupational Medicine \u201cB. 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