{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:07:16Z","timestamp":1781042836866,"version":"3.54.1"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purposes<\/jats:title>\n                    <jats:p>This study aimed at investigating the association between interleukin-6 (IL-6), interleukin-12 (IL-12), C-reactive protein (CRP), vascular endothelial growth factor (VEGF) and \u03b2-defensin-1 polymorphisms and the susceptibility to periodontitis in the Chinese population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>DNA was extracted from the blood samples of 532 healthy individuals and 122 chronic periodontitis (CP) patients enrolled in the study. The genes encoding IL-6, IL-12, CRP, VEGF and \u03b2-defensin-1 were amplified using PCR and digested with restriction enzymes. The protein expression of the abovementioned genes was determined by ELISA. Differences in the allele\/genotype frequencies were assessed with the chi-square test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The frequencies of the C\/C genotypes of IL-6, IL-12, and VEGF were higher in CP patients than healthy controls (66.3% vs 25.9%; 27.8% vs 19.9%; and 64.8% vs 52.1%, respectively). In the patients' group we also recorded frequencies of the A\/A genotypes of CRP and VEGF higher than in healthy controls (63.1% vs 58.1% and 64.8% vs 35.2%, respectively). Protein production evaluated by ELISA demonstrated significant differences between CP patients and healthy controls for IL-6, IL-12, CRP, VEGF and \u03b2-defensin-1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The genotypes of IL-6, IL-12, VEGF and \u03b2-defensin-1 and their protein productions were associated with CP in a Chinese population. Genotypes and serum levels of CRP were associated with CP, but alleles frequency showed no difference between CP patients and healthy controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/jbm.5000010","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T13:52:19Z","timestamp":1366725139000},"page":"100-107","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Association of Cytokines, High Sensitive C-Reactive Protein, VEGF and Beta-Defensin-1 Gene Polymorphisms and Their Protein Expressions with Chronic Periodontitis in the Chinese Population"],"prefix":"10.1177","volume":"28","author":[{"given":"Ye","family":"Tian","sequence":"first","affiliation":[{"name":"State Key Laboratory for Oral Diseases and Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, PR 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Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wings TY","family":"Loo","sequence":"additional","affiliation":[{"name":"UNIMED Medical Institute and Organisation for Oncology and Translational Research, Hong Kong - Hong Kong"},{"name":"School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong - Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary NB","family":"Cheung","sequence":"additional","affiliation":[{"name":"UNIMED Medical Institute and Organisation for Oncology and Translational Research, Hong Kong - Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis WC","family":"Chow","sequence":"additional","affiliation":[{"name":"UNIMED Medical Institute and Organisation for Oncology and Translational Research, Hong Kong - Hong 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