{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:45:21Z","timestamp":1784295921257,"version":"3.55.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to evaluate and compare cytokines in gingival crevicular fluid (GCF) and saliva of patients with aggressive periodontitis (AP) before and after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty AP patients and 40 healthy volunteers were enrolled in this study. Clinical parameters included probing depth and sulcus bleeding index. GCF and saliva were collected from both groups. The levels of IL-1\u03b2, IL-2, IL-4, IL-6, IFN-\u03b3 and TNF-\u03b1 were measured using ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The probing depth in AP patients was significantly deeper before treatment than after treatment. The concentrations of cytokines in GCF and saliva were significantly higher in AP patients than in the control group and decreased after periodontal treatment. Positive relationships were found between cytokine levels in GCF and clinical parameters. The reliability of cytokines in GCF and saliva was assessed by Cronbach's alpha analysis, which could be considered satisfactory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cytokine levels in GCF and saliva correlated well with clinical parameters and AP. Measurements of cytokines in saliva may be regarded as a noninvasive and quick method for monitoring periodontal disease activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/jbm.5000014","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T04:20:06Z","timestamp":1391746806000},"page":"108-112","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Comparative Evaluation of Cytokines in Gingival Crevicular Fluid and                     Saliva of Patients with Aggressive Periodontitis"],"prefix":"10.1177","volume":"28","author":[{"given":"Yuan","family":"Yue","sequence":"first","affiliation":[{"name":"State Key Laboratory for Oral Diseases and\r                Department of Prosthodontics, West China Hospital of Stomatology, Sichuan\r                University, Sichuan - PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"UNIMED Medical Institute and Organisation for\r                Oncology and Translational Research, Hong Kong SAR - PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral\r                Medicine, Xiangya Hospital, Central South University, Changsha, Hunan - PR\r                China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wings TY","family":"Loo","sequence":"additional","affiliation":[{"name":"UNIMED Medical Institute and Organisation for\r                Oncology and Translational Research, Hong Kong SAR - PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oral Diseases and\r                Department of Prosthodontics, West China Hospital of Stomatology, Sichuan\r                University, Sichuan - PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral\r                Medicine, Xiangya Hospital, Central South University, Changsha, Hunan - PR\r                China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary NB","family":"Cheung","sequence":"additional","affiliation":[{"name":"Jin Hua Dentistry, Chengdu, Sichuan - PR\r                China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-jun","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan - PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-ding","family":"Dou","sequence":"additional","affiliation":[{"name":"Jin Hua Dentistry, Chengdu, Sichuan - PR\r                China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis WC","family":"Chow","sequence":"additional","affiliation":[{"name":"UNIMED Medical Institute and Organisation for\r                Oncology and Translational Research, Hong Kong SAR - PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Hao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oral Diseases and\r                Department of Prosthodontics, West China Hospital of Stomatology, Sichuan\r                University, Sichuan - PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oral Diseases and\r                Department of Prosthodontics, West China Hospital of Stomatology, Sichuan\r                University, Sichuan - PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-le","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oral Diseases and\r                Department of Prosthodontics, West China Hospital of Stomatology, Sichuan\r                University, Sichuan - PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian YS","family":"Yip","sequence":"additional","affiliation":[{"name":"UNIMED Medical Institute and Organisation for\r                Oncology and Translational Research, Hong Kong SAR - PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth LY","family":"Ng","sequence":"additional","affiliation":[{"name":"UNIMED Medical Institute and Organisation for\r                Oncology and Translational Research, Hong Kong SAR - 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